Polycapsulated Silica Core Nanoparticles for Laser Tissue Soldering

Schönbächler, A.; Andereggen, L.; Möller, A.; Marti, D.; Guldimann, C.; Widmer, H.; Mevisen, M.; Frenz, Martin; Reinert, M. (2012). Polycapsulated Silica Core Nanoparticles for Laser Tissue Soldering. Journal of neurological surgery. Part A, Central European neurosurgery, 73(S 03). Thieme 10.1055/s-0032-1316250

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Introduction: Laser tissue fusion has a large potential for minimal invasive tissue fusion in different surgical specialties. We have developed a combined endovascular minimal invasive surgical technique to fuse blood vessels for bypass surgery. However, the main difficulty was to achieve reproducible results as the main tensile strength is a result of protein denaturation. We therefore aimed to develop a quantitative, reproducible tissue fusion using polycapsulated silica core nanoparticles containing indocyanine green (Si@PCL/ICG).

Methods: In a first step we developed mesoporous indocyanine green (ICG) containing nanoparticles and assessed their heating profile. Furthermore the stability to light exposure and ICG degradation was measured. In a second phase Si@PCL/ICG nanoparticles for embedding into a biodegradeable implant was developed and characterized using differential scanning calomeritry technique (DSC).

Results: ICG containing mesoporous silica nanoparticles showed a sufficient increase in temperature up to 80°C suitable for laser tissue fusion. However, long-term stability of ICG mesoporous nanoparticles is lost after 7 days of light exposure. In contrast Si@PCL/ICG nanoparticles demonstrated a strong heating capacity as well as a good DSC profile for laser tissue fusion and long-term stability of 3 weeks. Furthermore Si@PCL/ICG nanoparticles can be directly dispersed in spin-coated polycaprolactone polymer.

Conclusion: Si@PCL/ICG nanoparticles have good long-term stability and polymer embedding properties suitable for laser tissue fusion.

Item Type:	Conference or Workshop Item (Paper)
Division/Institute:	08 Faculty of Science > Institute of Applied Physics
UniBE Contributor:	Frenz, Martin
Subjects:	600 Technology > 620 Engineering 500 Science > 530 Physics
ISSN:	2193-6315
Publisher:	Thieme
Language:	English
Submitter:	Martin Frenz-Lips
Date Deposited:	05 Feb 2016 15:29
Last Modified:	05 Dec 2022 14:51
Publisher DOI:	10.1055/s-0032-1316250
URI:	https://boris.unibe.ch/id/eprint/75274