Polycapsulated Silica Core Nanoparticles for Laser Tissue Soldering

Schönbächler, A.; Andereggen, L.; Möller, A.; Marti, D.; Guldimann, C.; Widmer, H.; Mevisen, M.; Frenz, Martin; Reinert, M. (2012). Polycapsulated Silica Core Nanoparticles for Laser Tissue Soldering. Journal of neurological surgery. Part A, Central European neurosurgery, 73(S 03). Thieme 10.1055/s-0032-1316250

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Introduction: Laser tissue fusion has a large potential for minimal invasive tissue fusion in different surgical specialties. We have developed a combined endovascular minimal invasive surgical technique to fuse blood vessels for bypass surgery. However, the main difficulty was to achieve reproducible results as the main tensile strength is a result of protein denaturation. We therefore aimed to develop a quantitative, reproducible tissue fusion using polycapsulated silica core nanoparticles containing indocyanine green (Si@PCL/ICG). Methods: In a first step we developed mesoporous indocyanine green (ICG) containing nanoparticles and assessed their heating profile. Furthermore the stability to light exposure and ICG degradation was measured. In a second phase Si@PCL/ICG nanoparticles for embedding into a biodegradeable implant was developed and characterized using differential scanning calomeritry technique (DSC). Results: ICG containing mesoporous silica nanoparticles showed a sufficient increase in temperature up to 80°C suitable for laser tissue fusion. However, long-term stability of ICG mesoporous nanoparticles is lost after 7 days of light exposure. In contrast Si@PCL/ICG nanoparticles demonstrated a strong heating capacity as well as a good DSC profile for laser tissue fusion and long-term stability of 3 weeks. Furthermore Si@PCL/ICG nanoparticles can be directly dispersed in spin-coated polycaprolactone polymer. Conclusion: Si@PCL/ICG nanoparticles have good long-term stability and polymer embedding properties suitable for laser tissue fusion.

Item Type:

Conference or Workshop Item (Paper)

Division/Institute:

08 Faculty of Science > Institute of Applied Physics

UniBE Contributor:

Frenz, Martin

Subjects:

600 Technology > 620 Engineering
500 Science > 530 Physics

ISSN:

2193-6315

Publisher:

Thieme

Language:

English

Submitter:

Martin Frenz-Lips

Date Deposited:

05 Feb 2016 15:29

Last Modified:

31 Jan 2019 14:36

Publisher DOI:

10.1055/s-0032-1316250

URI:

https://boris.unibe.ch/id/eprint/75274

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