GetReal in network meta-analysis: a review of the methodology.

Efthimiou, Orestis; Debray, Thomas P A; van Valkenhoef, Gert; Trelle, Sven; Panayidou, Klea; Moons, Karel G M; Reitsma, Johannes B; Shang, Aijing; Salanti, Georgia (2016). GetReal in network meta-analysis: a review of the methodology. Research Synthesis Methods, 7(3), pp. 236-63. Wiley 10.1002/jrsm.1195

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Pairwise meta-analysis is an established statistical tool for synthesizing evidence from multiple trials, but it is informative only about the relative efficacy of two specific interventions. The usefulness of pairwise meta-analysis is thus limited in real-life medical practice, where many competing interventions may be available for a certain condition and studies informing some of the pairwise comparisons may be lacking. This commonly encountered scenario has led to the development of network meta-analysis (NMA). In the last decade, several applications, methodological developments, and empirical studies in NMA have been published, and the area is thriving as its relevance to public health is increasingly recognized. This article presents a review of the relevant literature on NMA methodology aiming to pinpoint the developments that have appeared in the field. Copyright © 2016 John Wiley & Sons, Ltd.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM)
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern

UniBE Contributor:

Trelle, Sven and Salanti, Georgia

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1759-2879

Publisher:

Wiley

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

19 Jan 2016 13:23

Last Modified:

23 Oct 2019 12:20

Publisher DOI:

10.1002/jrsm.1195

PubMed ID:

26754852

Uncontrolled Keywords:

comparing multiple interventions; indirect treatment comparison; mixed-treatment comparison; multiple-treatment meta-analysis

BORIS DOI:

10.7892/boris.75287

URI:

https://boris.unibe.ch/id/eprint/75287

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