Profiling invasiveness in head and neck cancer: recent contributions of genomic and transcriptomic approaches.

Nisa Hernandez, Lluis; Aebersold, Daniel; Giger, Roland; Caversaccio, Marco; Borner, Urs; Medova, Michaela; Zimmer, Yitzhak (2015). Profiling invasiveness in head and neck cancer: recent contributions of genomic and transcriptomic approaches. Cancers, 7(2), pp. 585-597. MDPI AG 10.3390/cancers7020585

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High-throughput molecular profiling approaches have emerged as precious research tools in the field of head and neck translational oncology. Such approaches have identified and/or confirmed the role of several genes or pathways in the acquisition/maintenance of an invasive phenotype and the execution of cellular programs related to cell invasion. Recently published new-generation sequencing studies in head and neck squamous cell carcinoma (HNSCC) have unveiled prominent roles in carcinogenesis and cell invasion of mutations involving NOTCH1 and PI3K-patwhay components. Gene-expression profiling studies combined with systems biology approaches have allowed identifying and gaining further mechanistic understanding into pathways commonly enriched in invasive HNSCC. These pathways include antigen-presenting and leucocyte adhesion molecules, as well as genes involved in cell-extracellular matrix interactions. Here we review the major insights into invasiveness in head and neck cancer provided by high-throughput molecular profiling approaches.

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