Eliçin, Olgun; Albrecht, Tobias; Haynes, Alan G; Bojaxhiu, Beat; Nisa Hernandez, Lluis; Caversaccio, Marco; Dal Pra, Alan; Schmücking, Michael; Aebersold, Daniel; Giger, Roland (2016). Outcomes in Advanced Head and Neck Cancer Treated with Up-front Neck Dissection prior to (Chemo)Radiotherapy. Otolaryngology - head and neck surgery, 154(2), pp. 300-308. Sage 10.1177/0194599815608370
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OBJECTIVE
Our aim was to compare outcomes with and without up-front neck dissection prior to (chemo)radiotherapy in head and neck squamous cell carcinoma.
STUDY DESIGN
Case series with chart review.
SETTING
Tertiary referral center.
SUBJECTS AND METHODS
Outcomes of oropharyngeal, laryngeal, and hypopharyngeal squamous cell carcinoma cases with neck lymph node metastases treated from January 2001 to March 2012 were analyzed. Due to imbalances in baseline characteristics between groups treated with (n = 129) and without (n = 95) up-front neck dissection, propensity score matching was performed.
RESULTS
Median follow-up was 48 months (range, 12-148). With up-front neck dissection, the hazard ratio for the primary end point, disease-free survival, was 0.63 (95% confidence interval: 0.37-1.06, P = .08). Up-front neck dissection reduced acute grade ≥3 toxicity significantly when xerostomia was excluded (odds ratio: 0.40, 95% confidence interval: 0.20-0.82, P = .012).
CONCLUSION
Our results indicate less acute treatment toxicity without any significant difference in terms of oncologic outcome with up-front neck dissection prior to (chemo)radiotherapy as compared with (chemo)radiotherapy alone. Well-designed randomized trials are required to verify this result and further investigate the impact of this strategy on late toxicity and oncologic outcome.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT) 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology |
UniBE Contributor: |
Eliçin, Olgun, Bojaxhiu, Beat, Nisa Hernandez, Lluis, Caversaccio, Marco, Dal Pra, Alan, Schmücking, Michael, Aebersold, Daniel Matthias, Giger, Roland |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0194-5998 |
Publisher: |
Sage |
Language: |
English |
Submitter: |
Beatrice Scheidegger |
Date Deposited: |
25 Apr 2016 14:57 |
Last Modified: |
02 Mar 2023 23:27 |
Publisher DOI: |
10.1177/0194599815608370 |
PubMed ID: |
26450749 |
Uncontrolled Keywords: |
head and neck squamous cell carcinoma, neck dissection, radiotherapy, toxicity, up-front |
BORIS DOI: |
10.7892/boris.75364 |
URI: |
https://boris.unibe.ch/id/eprint/75364 |
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