The aminoacyl-tRNA synthetases of Drosophila melanogaster

Lu, Jiongming; Marygold, Steven J; Gharib, Walid H; Suter, Beat (2015). The aminoacyl-tRNA synthetases of Drosophila melanogaster. Fly, 9(2), pp. 53-61. Taylor & Francis 10.1080/19336934.2015.1101196

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Aminoacyl-tRNA synthetases (aaRSs) ligate amino acids to their cognate tRNAs, allowing them to decode the triplet code during translation. Through different mechanisms aaRSs also perform several non-canonical functions in transcription, translation, apoptosis, angiogenesis and inflammation. Drosophila has become a preferred system to model human diseases caused by mutations in aaRS genes, to dissect effects of reduced translation or non-canonical activities, and to study aminoacylation and translational fidelity. However, the lack of a systematic annotation of this gene family has hampered such studies. Here, we report the identification of the entire set of aaRS genes in the fly genome and we predict their roles based on experimental evidence and/or orthology. Further, we propose a new, systematic and logical nomenclature for aaRSs. We also review the research conducted on Drosophila aaRSs to date. Together, our work provides the foundation for further research in the fly aaRS field.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Lu, Jiongming and Suter, Beat

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

1933-6934

Publisher:

Taylor & Francis

Funders:

[4] Swiss National Science Foundation
[52] Cancer Research Switzerland
[53] NIH National Human Genome Research Institute (NHGRI)

Language:

English

Submitter:

Beat Suter

Date Deposited:

11 Feb 2016 16:42

Last Modified:

22 Feb 2016 15:41

Publisher DOI:

10.1080/19336934.2015.1101196

BORIS DOI:

10.7892/boris.75494

URI:

https://boris.unibe.ch/id/eprint/75494

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