Polar Nature of Biomimetic Fluorapatite/Gelatin Composites: A Comparison of Bipolar Objects and the Polar State of Natural Tissue

Burgener, Matthias; Putzeys, Tristan; Parvinzadeh Gashti, Mazeyar; Busch, Susanne; Oulevey, Hanane; Wübbenhorst, Michael; Kniep, Rüdiger; Hulliger, Jürg (2015). Polar Nature of Biomimetic Fluorapatite/Gelatin Composites: A Comparison of Bipolar Objects and the Polar State of Natural Tissue. Biomacromolecules, 16(9), pp. 2814-2819. American Chemical Society 10.1021/acs.biomac.5b00770

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The correspondence of the state of alignment of macromolecules in biomimetic materials and natural tissues is demonstrated by investigating a mechanism of electrical polarity formation: An in vitro grown biomimetic FAp/gelatin composite is investigated for its polar properties by second harmonic (SHGM) and scanning pyroelectric microscopy (SPEM). Hexagonal prismatic seed crystals formed in gelatin gels represent a monodomain polar state, due to aligned mineralized gelatin molecules. Later growth stages, showing dumbbell morphologies, develop into a bipolar state because of surface recognition by gelatin functionality: A reversal of the polar alignment of macromolecules, thus, takes place close to that basal plane of the seed. In natural hard tissues (teeth and bone investigated by SPEM) and the biomimetic FAp/gelatin composite, we find a surprising analogy in view of growth-induced states of polarity: The development of polarity in vivo and in vitro can be explained by a Markov-type mechanism of molecular recognition during the attachment of macromolecules.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Burgener, Matthias; Parvinzadeh Gashti, Mazeyar; Oulevey, Hanane and Hulliger, Jürg

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1525-7797

Publisher:

American Chemical Society

Language:

English

Submitter:

Franziska Bornhauser-Rufer

Date Deposited:

25 Jan 2016 11:34

Last Modified:

27 Jan 2016 01:12

Publisher DOI:

10.1021/acs.biomac.5b00770

BORIS DOI:

10.7892/boris.75498

URI:

https://boris.unibe.ch/id/eprint/75498

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