Biomechanical Role of Bone Anisotropy Estimated on Clinical CT Scans by Image Registration

Taghizadeh, Elham; Reyes, Mauricio; Zysset, Philippe; Latypova, Adeliya; Terrier, Alexandre; Büchler, Philippe (2016). Biomechanical Role of Bone Anisotropy Estimated on Clinical CT Scans by Image Registration. Annals of biomedical engineering, 44(8), pp. 2505-2517. Springer 10.1007/s10439-016-1551-4

[img] Text
Taghizadeh et al. - Annals of biomedical engineering - 2016(2).pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (3MB) | Request a copy
[img]
Preview
Text
Taghizadeh_Elham_revision.pdf - Accepted Version
Available under License Publisher holds Copyright.

Download (6MB) | Preview

Image-based modeling is a popular approach to perform patient-specific biomechanical simulations. Accurate modeling is critical for orthopedic application to evaluate implant design and surgical planning. It has been shown that bone strength can be estimated from the bone mineral density (BMD) and trabecular bone architecture. However, these findings cannot be directly and fully transferred to patient-specific modeling since only BMD can be derived from clinical CT. Therefore, the objective of this study was to propose a method to predict the trabecular bone structure using a µCT atlas and an image registration technique. The approach has been evaluated on femurs and patellae under physiological loading. The displacement and ultimate force for femurs loaded in stance position were predicted with an error of 2.5% and 3.7%, respectively, while predictions obtained with an isotropic material resulted in errors of 7.3% and 6.9%. Similar results were obtained for the patella, where the strain predicted using the registration approach resulted in an improved mean squared error compared to the isotropic model. We conclude that the registration of anisotropic information from of a single template bone enables more accurate patient-specific simulations from clinical image datasets than isotropic model.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Taghizadeh, Elham; Reyes, Mauricio; Zysset, Philippe and Büchler, Philippe

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
600 Technology > 620 Engineering

ISSN:

0090-6964

Publisher:

Springer

Language:

English

Submitter:

Philippe Büchler

Date Deposited:

17 Feb 2016 10:32

Last Modified:

21 Jan 2017 02:30

Publisher DOI:

10.1007/s10439-016-1551-4

PubMed ID:

26790866

Uncontrolled Keywords:

Anisotropy; Femur; Finite element analysis (FEA); Patella; Trabecular bone

BORIS DOI:

10.7892/boris.75592

URI:

https://boris.unibe.ch/id/eprint/75592

Actions (login required)

Edit item Edit item
Provide Feedback