Cytotoxicity evaluation of polymer-derived ceramics for pacemaker electrode applications.

Grossenbacher, Jonas; Gullo, Maurizio R; Dalcanale, Federico; Blugan, Gurdial; Kuebler, Jakob; Lecaudé, Stéphanie; Tevaearai, Hendrik; Brugger, Juergen (2015). Cytotoxicity evaluation of polymer-derived ceramics for pacemaker electrode applications. Journal of biomedical materials research. Part A, 103(11), pp. 3625-3632. John Wiley & Sons 10.1002/jbm.a.35477

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Ceramics are known to be chemically stable, and the possibility to electrically dope polymer-derived ceramics makes it a material of interest for implantable electrode applications. We investigated cytotoxic characteristics of four polymer-derived ceramic candidates with either electrically conductive or insulating properties. Cytotoxicity was assessed by culturing C2C12 myoblast cells under two conditions: by exposing them to material extracts and by putting them directly in contact with material samples. Cell spreading was optically evaluated by comparing microscope observations immediately after the materials insertion and after 24 h culturing. Cell viability (MTT) and mortality (LDH) were quantified after 24-h incubation in contact with the materials. Comparison was made with biocompatible positive references (alumina, platinum, biocompatible stainless steel 1.4435), negative references (latex, stainless steel 1.4301) and controls (no material present in the culture wells). We found that the cytotoxic properties of tested ceramics are comparable to established reference materials. These ceramics, which are reported to be very stable, can be microstructured and electrically doped to a wide range of conductivity and are thus excellent candidates for implantable electrode applications including pacemakers.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Herz- und Gefässchirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Herz- und Gefässchirurgie

UniBE Contributor:

Lecaudé, Stéphanie and Tevaearai, Hendrik

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1549-3296

Publisher:

John Wiley & Sons

Language:

English

Submitter:

Daniela Huber

Date Deposited:

18 Feb 2016 12:54

Last Modified:

18 Feb 2016 12:54

Publisher DOI:

10.1002/jbm.a.35477

PubMed ID:

25851039

Uncontrolled Keywords:

cytotoxicity; implantable materials; myoblast; polymer-derived ceramic; variable conductivity

BORIS DOI:

10.7892/boris.75700

URI:

https://boris.unibe.ch/id/eprint/75700

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