Good reproducibility of heart rate variability after orthostatic challenge in patients with a history of acute coronary syndrome

Schäfer, Daniela; Nil, Markus; Herzig, David; Eser, Prisca; Saner, Hugo Ernst; Wilhelm, Matthias (2015). Good reproducibility of heart rate variability after orthostatic challenge in patients with a history of acute coronary syndrome. Journal of electrocardiology, 48(4), pp. 696-702. Elsevier 10.1016/j.jelectrocard.2015.04.004

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BACKGROUND: Several parameters of heart rate variability (HRV) have been shown to predict the risk of sudden cardiac death (SCD) in cardiac patients. There is consensus that risk prediction is increased when measuring HRV during specific provocations such as orthostatic challenge. For the first time, we provide data on reproducibility of such a test in patients with a history of acute coronary syndrome. METHODS: Sixty male patients (65+/-8years) with a history of acute coronary syndrome on stable medication were included. HRV was measured in supine (5min) and standing (5min) position on 2 occasions separated by two weeks. For risk assessment relevant time-domain [standard deviation of all R-R intervals (SDNN) and root mean squared standard differences between adjacent R-R intervals (RMSSD)], frequency domain [low-frequency power (LF), high-frequency power (HF) and LF/HF power ratio] and short-term fractal scaling component (DF1) were computed. Absolute reproducibility was assessed with the standard errors of the mean (SEM) and 95% limits of random variation, and relative reproducibility by the intraclass correlation coefficient (ICC). RESULTS: We found comparable SEMs and ICCs in supine position and after an orthostatic challenge test. All ICCs were good to excellent (ICCs between 0.636 and 0.869). CONCLUSIONS: Reproducibility of HRV parameters during orthostatic challenge is good and comparable with supine position.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Schäfer, Daniela; Herzig, David; Eser, Prisca; Saner, Hugo Ernst and Wilhelm, Matthias

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1532-8430

Publisher:

Elsevier

Language:

English

Submitter:

Matthias Wilhelm

Date Deposited:

27 Apr 2016 07:59

Last Modified:

24 Apr 2017 17:38

Publisher DOI:

10.1016/j.jelectrocard.2015.04.004

PubMed ID:

25935350

Uncontrolled Keywords:

Autonomic nervous system; Coronary artery disease; Ectopic beat; Orthostatic test; Risk assessment

BORIS DOI:

10.7892/boris.75787

URI:

https://boris.unibe.ch/id/eprint/75787

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