Alwan, Heba; Ehret, Georg; Ponte, Belen; Pruijm, Menno; Ackermann, Daniel; Guessous, Idris; Staessen, Jan A; Asayama, Kei; Kutalik, Zoltán; Vuistiner, Philippe; Paccaud, Fred; Pechere-Bertschi, Antoinette; Mohaupt, Markus; Vogt, Bruno; Martin, Pierre-Yves; Burnier, Michel; Bochud, Murielle (2015). Heritability of ambulatory and office blood pressure in the Swiss population. Journal of hypertension, 33(10), pp. 2061-2067. Lippincott Williams & Wilkins 10.1097/HJH.0000000000000681
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BACKGROUND
Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are population-specific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample.
METHODS
The Swiss Kidney Project on Genes in Hypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software.
RESULTS
The 518 women and 491 men included in this analysis had a mean (±SD) age of 48.3 (±17.4) and 47.3 (±17.7) years, and a mean BMI of 23.8 (±4.2) and 25.9 (±4.1) kg/m, respectively. Narrow-sense heritability estimates (±standard error) for ambulatory SBP, DBP, and pulse pressure were 0.37 ± 0.07, 0.26 ± 0.07, and 0.29 ± 0.07 for 24-h BP; 0.39 ± 0.07, 0.28 ± 0.07, and 0.27 ± 0.07 for day BP; and 0.25 ± 0.07, 0.20 ± 0.07, and 0.30 ± 0.07 for night BP, respectively (all P < 0.001). Heritability estimates for office SBP, DBP, and pulse pressure were 0.21 ± 0.08, 0.25 ± 0.08, and 0.18 ± 0.07 (all P < 0.01).
CONCLUSIONS
We found significant heritability estimates for both ambulatory and office BP in this Swiss population-based study. Our findings justify the ongoing search for the genetic determinants of BP.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension |
UniBE Contributor: |
Ackermann, Daniel, Mohaupt, Markus, Vogt, Bruno |
Subjects: |
600 Technology > 610 Medicine & health 500 Science 500 Science > 570 Life sciences; biology |
ISSN: |
0263-6352 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Daniel Ackermann |
Date Deposited: |
01 Mar 2016 13:41 |
Last Modified: |
05 Dec 2022 14:51 |
Publisher DOI: |
10.1097/HJH.0000000000000681 |
PubMed ID: |
26203966 |
BORIS DOI: |
10.7892/boris.75818 |
URI: |
https://boris.unibe.ch/id/eprint/75818 |
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