Heritability of ambulatory and office blood pressure in the Swiss population

Alwan, Heba; Ehret, Georg; Ponte, Belen; Pruijm, Menno; Ackermann, Daniel; Guessous, Idris; Staessen, Jan A; Asayama, Kei; Kutalik, Zoltán; Vuistiner, Philippe; Paccaud, Fred; Pechere-Bertschi, Antoinette; Mohaupt, Markus; Vogt, Bruno; Martin, Pierre-Yves; Burnier, Michel; Bochud, Murielle (2015). Heritability of ambulatory and office blood pressure in the Swiss population. Journal of hypertension, 33(10), pp. 2061-2067. Lippincott Williams & Wilkins 10.1097/HJH.0000000000000681

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BACKGROUND Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are population-specific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample. METHODS The Swiss Kidney Project on Genes in Hypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software. RESULTS The 518 women and 491 men included in this analysis had a mean (±SD) age of 48.3 (±17.4) and 47.3 (±17.7) years, and a mean BMI of 23.8 (±4.2) and 25.9 (±4.1) kg/m, respectively. Narrow-sense heritability estimates (±standard error) for ambulatory SBP, DBP, and pulse pressure were 0.37 ± 0.07, 0.26 ± 0.07, and 0.29 ± 0.07 for 24-h BP; 0.39 ± 0.07, 0.28 ± 0.07, and 0.27 ± 0.07 for day BP; and 0.25 ± 0.07, 0.20 ± 0.07, and 0.30 ± 0.07 for night BP, respectively (all P < 0.001). Heritability estimates for office SBP, DBP, and pulse pressure were 0.21 ± 0.08, 0.25 ± 0.08, and 0.18 ± 0.07 (all P < 0.01). CONCLUSIONS We found significant heritability estimates for both ambulatory and office BP in this Swiss population-based study. Our findings justify the ongoing search for the genetic determinants of BP.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Ackermann, Daniel; Mohaupt, Markus and Vogt, Bruno

Subjects:

600 Technology > 610 Medicine & health
500 Science
500 Science > 570 Life sciences; biology

ISSN:

0263-6352

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Daniel Ackermann

Date Deposited:

01 Mar 2016 13:41

Last Modified:

01 Nov 2016 02:30

Publisher DOI:

10.1097/HJH.0000000000000681

PubMed ID:

26203966

BORIS DOI:

10.7892/boris.75818

URI:

https://boris.unibe.ch/id/eprint/75818

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