Associations of Urinary Uromodulin with Clinical Characteristics and Markers of Tubular Function in the General Population

Pruijm, Menno; Ponte, Belen; Ackermann, Daniel; Paccaud, Fred; Guessous, Idris; Ehret, Georg; Pechère-Bertschi, Antoinette; Vogt, Bruno; Mohaupt, Markus; Martin, Pierre-Yves; Youhanna, Sonia C; Nägele, Nadine; Vollenweider, Peter; Waeber, Gérard; Burnier, Michel; Devuyst, Olivier; Bochud, Murielle (2016). Associations of Urinary Uromodulin with Clinical Characteristics and Markers of Tubular Function in the General Population. Clinical journal of the American Society of Nephrology, 11(1), pp. 70-80. American Society of Nephrology 10.2215/CJN.04230415

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BACKGROUND AND OBJECTIVES Allelic variants in UMOD, the gene coding for uromodulin, are associated with rare tubulointerstitial kidney disorders and risk of CKD and hypertension in the general population. The factors associated with uromodulin excretion in the normal population remain largely unknown, and were therefore explored in this study. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Urinary uromodulin excretion was measured using a validated ELISA in two population-based cohorts that included more than 6500 individuals. The Swiss Kidney Project on Genes in Hypertension study (SKIPOGH) included 817 adults (mean age±SD, 45±17 years) who underwent renal ultrasonography and performed a 24-hour urine collection. The Cohorte Lausannoise study included 5706 adults (mean age, 53±11 years) with fresh spot morning urine samples. We calculated eGFRs using the CKD-Epidemiology Collaboration formula and by 24-hour creatinine clearance. RESULTS In both studies, positive associations were found between uromodulin and urinary sodium, chloride, and potassium excretion and osmolality. In SKIPOGH, 24-hour uromodulin excretion (median, 41 [interquartile range, 29-57] mg/24 h) was positively associated with kidney length and volume and with creatinine excretion and urine volume. It was negatively associated with age and diabetes. Both spot uromodulin concentration and 24-hour uromodulin excretion were linearly and positively associated (multivariate analyses) with eGFR<90 ml/min per 1.73 m(2). CONCLUSION Age, creatinine excretion, diabetes, and urinary volume are independent clinical correlates of urinary uromodulin excretion. The associations of uromodulin excretion with markers of tubular functions and kidney dimensions suggest that it may reflect tubule activity in the general population.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Ackermann, Daniel; Vogt, Bruno and Mohaupt, Markus

Subjects:

600 Technology > 610 Medicine & health
500 Science
500 Science > 570 Life sciences; biology

ISSN:

1555-9041

Publisher:

American Society of Nephrology

Language:

English

Submitter:

Daniel Ackermann

Date Deposited:

01 Mar 2016 13:49

Last Modified:

01 Mar 2016 13:49

Publisher DOI:

10.2215/CJN.04230415

PubMed ID:

26683888

Uncontrolled Keywords:

electrolytes; glomerular filtration rate; humans; hypertension, renal; osmolality; potassium; renal insufficiency, chronic; renal tubular cells; sodium; uromodulin

BORIS DOI:

10.7892/boris.75821

URI:

https://boris.unibe.ch/id/eprint/75821

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