Quantitative multi-slice computed tomography assessment of the mitral valvular complex for transcatheter mitral valve interventions part 1: systematic measurement methodology and inter-observer variability

Thériault-Lauzier, Pascal; Mylotte, Darren; Dorfmeister, Magdalena; Spaziano, Marco; Andalib, Ali; Mamane, Samuel; Chetrit, Michael; Blanke, Philipp; Cecere, Renzo; Buithieu, Jean; Martucci, Giuseppe; Tchetche, Didier; Modine, Thomas; van Mieghem, Nicolas; Lange, Rüdiger; Windecker, Stephan; Bilodeau, Luc; Leipsic, Jonathon; Piazza, Nicolo (2015). Quantitative multi-slice computed tomography assessment of the mitral valvular complex for transcatheter mitral valve interventions part 1: systematic measurement methodology and inter-observer variability. EuroIntervention, 11(7), e1011-e1020. Europa Digital & Publishing 10.4244/EIJY15M11_09

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AIMS Transcatheter mitral valve replacement (TMVR) is an emerging technology with the potential to treat patients with severe mitral regurgitation at excessive risk for surgical mitral valve surgery. Multimodal imaging of the mitral valvular complex and surrounding structures will be an important component for patient selection for TMVR. Our aim was to describe and evaluate a systematic multi-slice computed tomography (MSCT) image analysis methodology that provides measurements relevant for transcatheter mitral valve replacement. METHODS AND RESULTS A systematic step-by-step measurement methodology is described for structures of the mitral valvular complex including: the mitral valve annulus, left ventricle, left atrium, papillary muscles and left ventricular outflow tract. To evaluate reproducibility, two observers applied this methodology to a retrospective series of 49 cardiac MSCT scans in patients with heart failure and significant mitral regurgitation. For each of 25 geometrical metrics, we evaluated inter-observer difference and intra-class correlation. The inter-observer difference was below 10% and the intra-class correlation was above 0.81 for measurements of critical importance in the sizing of TMVR devices: the mitral valve annulus diameters, area, perimeter, the inter-trigone distance, and the aorto-mitral angle. CONCLUSIONS MSCT can provide measurements that are important for patient selection and sizing of TMVR devices. These measurements have excellent inter-observer reproducibility in patients with functional mitral regurgitation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Windecker, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1774-024X

Publisher:

Europa Digital & Publishing

Language:

English

Submitter:

Judith Liniger

Date Deposited:

06 Apr 2016 11:45

Last Modified:

10 Oct 2016 01:36

Publisher DOI:

10.4244/EIJY15M11_09

PubMed ID:

26606733

URI:

https://boris.unibe.ch/id/eprint/75896

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