QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies

Whiting, Penny F; Rutjes, Anne W S; Westwood, Marie E; Mallett, Susan; Deeks, Jonathan J; Reitsma, Johannes B; Leeflang, Mariska M G; Sterne, Jonathan A C; Bossuyt, Patrick M M (2011). QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Annals of internal medicine, 155(8), pp. 529-536. Philadelphia, Pa.: American College of Physicians 10.1059/0003-4819-155-8-201110180-00009

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In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Rutjes, Anne

ISSN:

0003-4819

Publisher:

American College of Physicians

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:22

Last Modified:

10 Sep 2017 08:54

Publisher DOI:

10.1059/0003-4819-155-8-201110180-00009

PubMed ID:

22007046

Web of Science ID:

000296066300018

BORIS DOI:

10.7892/boris.7590

URI:

https://boris.unibe.ch/id/eprint/7590 (FactScience: 212885)

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