Very Late Scaffold Thrombosis: Intracoronary Imaging and Histopathological and Spectroscopic Findings.

Räber, Lorenz; Brugaletta, Salvatore; Yamaji, Kyohei; O'Sullivan, Crochan J; Otsuki, Shuji; Koppara, Tobias; Taniwaki, Masanori; Onuma, Yoshinobu; Freixa, Xavier; Eberli, Franz R; Serruys, Patrick W; Joner, Michael; Sabaté, Manel; Windecker, Stephan (2015). Very Late Scaffold Thrombosis: Intracoronary Imaging and Histopathological and Spectroscopic Findings. Journal of the American College of Cardiology, 66(17), pp. 1901-1914. Elsevier 10.1016/j.jacc.2015.08.853

Text 1-s2.0-S0735109715058234-main.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (9MB)

BACKGROUND

Bioresorbable scaffolds provide transient lumen support followed by complete resorption.

OBJECTIVES

This study examined whether very late scaffold thrombosis (VLScT) occurs when resorption is presumed to be nearly complete.

METHODS

Patients with VLScT at 3 tertiary care centers underwent thrombus aspiration followed by optical coherence tomography (OCT). Thrombus aspirates were analyzed by histopathological and spectroscopic examination.

RESULTS

Between March 2014 and February 2015, 4 patients presented with VLScT at 44 (case 1), 19 (cases 2 and 4), and 21 (case 3) months, respectively, after implantation of an Absorb Bioresorbable Vascular Scaffold 1.1 (Abbott Laboratories, Abbott Park, Illinois). At the time of VLScT, all patients were taking low-dose aspirin, and 2 patients were also taking prasugrel. OCT showed malapposed scaffold struts surrounded by thrombus in 7.1%, 9.0%, and 8.9% of struts in cases 1, 2, and 4, respectively. Scaffold discontinuity with struts in the lumen center was the cause of malapposition in cases 2 and 4. Uncovered scaffold struts with superimposed thrombus were the predominant findings in case 3. OCT percent area stenosis at the time of VLScT was high in case 1 (74.8%) and case 2 (70.9%) without evidence of excessive neointimal hyperplasia. Spectroscopic thrombus aspirate analysis showed persistence of intracoronary polymer fragments in case 1.

CONCLUSIONS

VLScT may occur at advanced stages of scaffold resorption. Potential mechanisms specific for VLScT include scaffold discontinuity and restenosis during the resorption process, which appear delayed in humans; these findings suggest an extended period of vulnerability for thrombotic events.

Interest & Impact

Downloads

1 since deposited on 17 Mar 2016
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item