Validity of SYNTAX score II for risk stratification of percutaneous coronary interventions: A patient-level pooled analysis of 5,433 patients enrolled in contemporary coronary stent trials.

Campos, Carlos M; Garcia-Garcia, Hector M; van Klaveren, David; Ishibashi, Yuki; Cho, Yun-Kyeong; Valgimigli, Marco; Räber, Lorenz; Jonker, Hans; Onuma, Yoshinobu; Farooq, Vasim; Garg, Scot; Windecker, Stephan; Morel, Marie-Angele; Steyerberg, Ewout W; Serruys, Patrick W (2015). Validity of SYNTAX score II for risk stratification of percutaneous coronary interventions: A patient-level pooled analysis of 5,433 patients enrolled in contemporary coronary stent trials. International journal of cardiology, 187, pp. 111-115. Elsevier 10.1016/j.ijcard.2015.03.248

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OBJECTIVES

To assess the clinical profile and long-term mortality in SYNTAX score II based strata of patients who received percutaneous coronary interventions (PCI) in contemporary randomized trials.

BACKGROUND

The SYNTAX score II was developed in the randomized, all-comers' SYNTAX trial population and is composed by 2 anatomical and 6 clinical variables. The interaction of these variables with the treatment provides individual long-term mortality predictions if a patient undergoes coronary artery bypass grafting (CABG) or PCI.

METHODS

Patient-level (n=5433) data from 7 contemporary coronary drug-eluting stent (DES) trials were pooled. The mortality for CABG or PCI was estimated for every patient. The difference in mortality estimates for these two revascularization strategies was used to divide the patients into three groups of theoretical treatment recommendations: PCI, CABG or PCI/CABG (the latter means equipoise between CABG and PCI for long term mortality).

RESULTS

The three groups had marked differences in their baseline characteristics. According to the predicted risk differences, 5115 patients could be treated either by PCI or CABG, 271 should be treated only by PCI and, rarely, CABG (n=47) was recommended. At 3-year follow-up, according to the SYNTAX score II recommendations, patients recommended for CABG had higher mortality compared to the PCI and PCI/CABG groups (17.4%; 6.1% and 5.3%, respectively; P<0.01).

CONCLUSIONS

The SYNTAX score II demonstrated capability to help in stratifying PCI procedures.

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