Impact of body mass index on long-term clinical outcomes after second-generation drug eluting stent implantation: Insights from the international global RESOLUTE program

Diletti, Roberto; Garcia-Garcia, Hector M; Bourantas, Christos; Van Mieghem, Nicolas M; van Geuns, Robert Jan; Muramatsu, Takashi; Zhang, Yao-Jun; Mauri, Laura; Belardi, Jorge; Silber, Sigmund; Widimsky, Petr; Leon, Martin; Windecker, Stephan; Meredith, Ian; Neumann, Franz-Josef; Yeung, Alan C; Saito, Shigeru; Liu, Minglei; van Leeuwen, Frank and Serruys, Patrick W (2015). Impact of body mass index on long-term clinical outcomes after second-generation drug eluting stent implantation: Insights from the international global RESOLUTE program. Catheterization and cardiovascular interventions, 85(6), pp. 952-958. Wiley-Blackwell 10.1002/ccd.25828

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BACKGROUND An increased body mass index (BMI) is associated with a high risk of cardiovascular disease and reduction in life expectancy. However, several studies reported improved clinical outcomes in obese patients treated for cardiovascular diseases. The aim of the present study is to investigate the impact of BMI on long-term clinical outcomes after implantation of zotarolimus eluting stents. METHODS Individual patient data were pooled from the RESOLUTE Clinical Program comprising five trials worldwide. The study population was sorted according to BMI tertiles and clinical outcomes were evaluated at 2-year follow-up. RESULTS Data from a total of 5,127 patients receiving the R-ZES were included in the present study. BMI tertiles were as follow: I tertile (≤ 25.95 kg/m(2) -Low or normal weight) 1,727 patients; II tertile (>25.95 ≤ 29.74 kg/m(2) -overweight) 1,695 patients, and III tertile (>29.74 kg/m(2) -obese) 1,705 patients. At 2-years follow-up no difference was found for patients with high BMI (III tertile) compared with patients with normal or low BMI (I tertile) in terms of target lesion failure (I-III tertile, HR [95% CI] = 0.89 [0.69, 1.14], P = 0.341; major adverse cardiac events (I-III tertile, HR [95% CI] = 0.90 [0.72, 1.14], P = 0.389; cardiac death (I-III tertile, HR [95% CI] = 1.20 [0.73, 1.99], P = 0.476); myocardial infarction (I-III tertile, HR [95% CI] = 0.86 [0.55, 1.35], P = 0.509; clinically-driven target lesion revascularization (I-III tertile, HR [95% CI] = 0.75 [0.53, 1.08], P = 0.123; definite or probable stent thrombosis (I-III tertile, HR [95% CI] = 0.98 [0.49, 1.99], P = 0.964. CONCLUSIONS In the present study, the patients' body mass index was found to have no impact on long-term clinical outcomes after coronary artery interventions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Windecker, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1522-1946

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Judith Liniger

Date Deposited:

25 Feb 2016 10:22

Last Modified:

25 Feb 2016 10:24

Publisher DOI:

10.1002/ccd.25828

PubMed ID:

25689692

Uncontrolled Keywords:

coronary artery disease; obesity paradox; zotarolimus eluting stents

BORIS DOI:

10.7892/boris.75940

URI:

https://boris.unibe.ch/id/eprint/75940

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