Life style habits such as alcohol consumption and physical activity in relation to serum apoB / apoA-I ratio amongst 64-year-old women with varying degrees of glucose tolerance.

Simonsson, M; Schmidt, C; Sigurdardottir, Vilborg; Helenius, M-L; Fagerberg, B (2007). Life style habits such as alcohol consumption and physical activity in relation to serum apoB / apoA-I ratio amongst 64-year-old women with varying degrees of glucose tolerance. Journal of internal medicine, 262(5), pp. 537-544. Blackwell Scientific Publications 10.1111/j.1365-2796.2007.01866.x

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OBJECTIVES

To investigate how life style factors such as alcohol consumption and physical activity relate to the serum apoB / apoA-I ratio in a cohort of middle-aged women with varying degrees of glucose tolerance.

DESIGN

Observational, cross-sectional cohort study.

SETTING

Research laboratory at a University Hospital.

SUBJECTS

A screened cohort of 64-year-old postmenopausal women with varying degrees of glucose tolerance, ranging from diabetes (n = 232), impaired (n = 212) and normal (n = 191) glucose tolerance.

MAIN OUTCOME MEASURE

ApoB / apoA-I ratio in relation to alcohol consumption and physical activity as assessed by questionnaires.

RESULTS

Alcohol consumption and regular physical activity at high levels were inversely associated with the serum apoB / apoA-I ratio independently of confounding factors such as obesity, lipid-lowering treatment, degree of glucose tolerance and hormone replacement therapy. Alcohol seemed related to the apoB / apoA-I ratio mainly through increasing apoA-I, whereas physical activity seemed mainly related to lowering of apoB. Alcohol consumption above a daily intake of 8.9 g, i.e. less than a glass of wine was accompanied by a decrease in apoB / apoA-I ratio.

CONCLUSIONS

Amongst these 64-year-old women with varying degrees of glucose tolerance, a moderate alcohol intake and regular physical exercise leading to sweating were associated with lower apoB / apoA-I ratio and these effects seem to be additive.

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6 Citations in Scopus

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