Is The Allergen Really Needed in Allergy Immunotherapy?

Kündig, Thomas M; Klimek, Ludger; Schendzielorz, Philipp; Renner, Wolfgang A; Senti, Gabriela; Bachmann, Martin (2015). Is The Allergen Really Needed in Allergy Immunotherapy? Current Treatment Options in Allergy, 2(1), pp. 72-82. Springer 10.1007/s40521-014-0038-5

[img]
Preview
Text
40521_2014_Article_38.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (660kB) | Preview

Immunotherapy for type I allergies is well established and is regarded to be the most efficient treatment option besides allergen avoidance. As of today, different forms of allergen preparations are used in this regard, as well as different routes of application. Virus-like particles (VLPs) represent a potent vaccine platform with proven immunogenicity and clinical efficacy. The addition of toll-like receptor ligands and/or depot-forming adjuvants further enhances activation of innate as well as adaptive immune responses. CpG motifs represent intensively investigated and potent direct stimulators of plasmacytoid dendritic cells and B cells, while T cell responses are enhanced indirectly through increased antigen presentation and cytokine release. This article will focus on the function of VLPs loaded with DNA rich in nonmethylated CG motifs (CpGs) and the clinical experience gained in the treatment of allergic rhinitis, demonstrating clinical efficacy also if administered without allergens. Several published studies have demonstrated a beneficial impact on allergic symptoms by treatment with CpG-loaded VLPs. Subcutaneous injection of VLPs loaded with CpGs was tested with or without the adjuvant alum in the presence or absence of an allergen. The results encourage further investigation of VLPs and CpG motifs in immunotherapy, either as a stand-alone product or as adjuvants for allergen-specific immunotherapy.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Bachmann, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2196-3053

Publisher:

Springer

Language:

English

Submitter:

Nathalie Taiana

Date Deposited:

02 Mar 2016 10:58

Last Modified:

20 Mar 2021 05:49

Publisher DOI:

10.1007/s40521-014-0038-5

PubMed ID:

25722959

Uncontrolled Keywords:

Allergic rhinitis; Allergy; CpG motifs; Immunotherapy; Vaccine; Virus-like particles

BORIS DOI:

10.7892/boris.76235

URI:

https://boris.unibe.ch/id/eprint/76235

Actions (login required)

Edit item Edit item
Provide Feedback