Successful Treatment of Recalcitrant Prurigo with Alitretinoin

Gadaldi, Karolina; Erdemoğlu, Yeliz; Yawalkar, Nikhil (2015). Successful Treatment of Recalcitrant Prurigo with Alitretinoin. Dermatology, 231(4), pp. 330-333. Karger 10.1159/000435911

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BACKGROUND Chronic itch with secondary scratch lesions such as prurigo has a major impact on quality of life. Due to its relapsing nature and often unknown origin, its treatment is challenging. OBJECTIVE We sought to demonstrate that alitretinoin can be an efficacious and well-tolerated treatment in a patient suffering from chronic itch with concomitant prurigo and psoriatic lesions. METHODS Case report. RESULTS After 1 month of alitretinoin treatment (30 mg daily), itch as well as prurigo and psoriasis lesions decreased markedly. Three cycles of alitretinoin were administered, as each cessation of treatment led to relapse of the symptoms after 6-8 weeks. Tapering of the alitretinoin dose (30 mg every second day) after the third cycle allowed to maintain the effects for over 18 months. CONCLUSION Treatment of refractory prurigo with alitretinoin might be an efficacious alternative to standard therapies. In case of relapse, retreatment with alitretinoin reinduces a further long-lasting response.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Gadaldi, Karolina and Yawalkar, Nikhil

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1018-8665

Publisher:

Karger

Language:

English

Submitter:

Sandra Nyffenegger

Date Deposited:

16 Mar 2016 15:48

Last Modified:

09 Sep 2017 02:13

Publisher DOI:

10.1159/000435911

PubMed ID:

26304762

BORIS DOI:

10.7892/boris.76252

URI:

https://boris.unibe.ch/id/eprint/76252

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