Sentinel lymph node biopsy in thick malignant melanoma: A 16-year single unit experience.

Hunger, Robert; Michel, Aude; Seyed Jafari, Seyed Morteza; Shafighi, Maziar (2015). Sentinel lymph node biopsy in thick malignant melanoma: A 16-year single unit experience. European journal of dermatology EJD, 25(5), pp. 472-476. John Libbey Eurotext 10.1684/ejd.2015.2626

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BACKGROUND The role of sentinel lymph node biopsy (SLNB) and its benefits in patients with thick melanoma is still controversial. OBJECTIVES We evaluated the clinical effect of SLNB in patients with thick melanoma. METHODS We performed a retrospective cohort review (1996-2012) of thick melanomas. Collected data included the patient and tumour characteristics. Locoregional recurrence, distant metastases, disease free and overall survival were compared between the patients with positive and negative SLNB. RESULTS 126 thick melanomas with a mean age of 64.09 years were included in the study. Positive SLNB were found in 47 (37.3%) patients. Significantly more locoregional recurrence (P = 0.002) and distant metastases (P = 0.030) were detected in the patients with positive SLNB. Furthermore, the patients with negative SLNB showed significantly better disease free survival (P = 0.021). CONCLUSIONS Positive SLNB might be prognostic factor in thick melanoma and aggravates the outcome of thick melanomas.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery > Plastic, Reconstructive and Aesthetic Surgery
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Hunger, Robert; Seyed Jafari, Seyed Morteza and Shafighi, Maziar


600 Technology > 610 Medicine & health




John Libbey Eurotext




Sandra Nyffenegger

Date Deposited:

29 Feb 2016 15:17

Last Modified:

15 Sep 2017 23:51

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

outcome; sentinel lymph node biopsy; thick melanoma




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