Poly-N-acetyl glucosamine nanofibers for negative-pressure wound therapies

Fulco, Ilario; Erba, Paolo; Valeri, Robert C; Vournakis, John; Schaefer, Dirk J (2015). Poly-N-acetyl glucosamine nanofibers for negative-pressure wound therapies. Wound repair and regeneration, 23(2), pp. 197-202. Wiley-Blackwell 10.1111/wrr.12273

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The wound healing promoting effect of negative wound pressure therapies (NPWT) takes place at the wound interface. The use of bioactive substances at this site represents a major research area for the development of future NPWT therapies. To assess wound healing kinetics in pressure ulcers treated by NPWT with or without the use of a thin interface membrane consisting of poly-N-acetyl glucosamine nanofibers (sNAG) a prospective randomized clinical trial was performed. The safety of the combination of NPWT and sNAG was also assessed in patients treated with antiplatelet drugs. In the performed study, the combination of NPWT and sNAG in 10 patients compared to NPWT alone in 10 patients promoted wound healing due to an improved contraction of the wound margins (p = 0.05) without a change in wound epithelization. In 6 patients treated with antiplatelet drugs no increased wound bleeding was observed in patients treated by NPWT and sNAG. In conclusion, the application of thin membranes of sNAG nanofibers at the wound interface using NPWT was safe and augmented the action of NPWT leading to improved wound healing due to a stimulation of wound contraction.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)

UniBE Contributor:

Erba, Paolo

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1067-1927

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Markus Huth

Date Deposited:

02 Mar 2016 13:56

Last Modified:

02 Mar 2016 13:56

Publisher DOI:

10.1111/wrr.12273

PubMed ID:

25703411

BORIS DOI:

10.7892/boris.76316

URI:

https://boris.unibe.ch/id/eprint/76316

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