Scherrer, Urs; Rimoldi, Stefano; Sartori, Claudio; Messerli, Franz; Rexhaj, Emrush (2015). Fetal programming and epigenetic mechanisms in arterial hypertension. Current opinion in cardiology, 30(4), pp. 393-397. Lippincott Williams & Wilkins 10.1097/HCO.0000000000000192
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PURPOSE OF REVIEW
To provide an overview of available evidence of the potential role of epigenetics in the pathogenesis of hypertension and vascular dysfunction.
RECENT FINDINGS
Arterial hypertension is a highly heritable condition. Surprisingly, however, genetic variants only explain a tiny fraction of the phenotypic variation and the term 'missing heritability' has been coined to describe this phenomenon. Recent evidence suggests that phenotypic alteration that is unrelated to changes in DNA sequence (thereby escaping detection by classic genetic methodology) offers a potential explanation. Here, we present some basic information on epigenetics and review recent work consistent with the hypothesis of epigenetically induced arterial hypertension.
SUMMARY
New technologies that enable the rigorous assessment of epigenetic changes and their phenotypic consequences may provide the basis for explaining the missing heritability of arterial hypertension and offer new possibilities for treatment and/or prevention.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Scherrer, Urs, Rimoldi, Stefano, Messerli, Franz, Rexhaj, Emrush |
Subjects: |
600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology |
ISSN: |
0268-4705 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Stefano Rimoldi |
Date Deposited: |
11 May 2016 13:58 |
Last Modified: |
05 Dec 2022 14:52 |
Publisher DOI: |
10.1097/HCO.0000000000000192 |
PubMed ID: |
26049388 |
BORIS DOI: |
10.7892/boris.76417 |
URI: |
https://boris.unibe.ch/id/eprint/76417 |
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