Fetal programming and epigenetic mechanisms in arterial hypertension.

Scherrer, Urs; Rimoldi, Stefano; Sartori, Claudio; Messerli, Franz; Rexhaj, Emrush (2015). Fetal programming and epigenetic mechanisms in arterial hypertension. Current opinion in cardiology, 30(4), pp. 393-397. Lippincott Williams & Wilkins 10.1097/HCO.0000000000000192

[img]
Preview
Text
00001573-201507000-00015.pdf - Published Version
Available under License Publisher holds Copyright.

Download (357kB) | Preview

PURPOSE OF REVIEW To provide an overview of available evidence of the potential role of epigenetics in the pathogenesis of hypertension and vascular dysfunction. RECENT FINDINGS Arterial hypertension is a highly heritable condition. Surprisingly, however, genetic variants only explain a tiny fraction of the phenotypic variation and the term 'missing heritability' has been coined to describe this phenomenon. Recent evidence suggests that phenotypic alteration that is unrelated to changes in DNA sequence (thereby escaping detection by classic genetic methodology) offers a potential explanation. Here, we present some basic information on epigenetics and review recent work consistent with the hypothesis of epigenetically induced arterial hypertension. SUMMARY New technologies that enable the rigorous assessment of epigenetic changes and their phenotypic consequences may provide the basis for explaining the missing heritability of arterial hypertension and offer new possibilities for treatment and/or prevention.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Scherrer, Urs; Rimoldi, Stefano; Messerli, Franz and Rexhaj, Emrush

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0268-4705

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Stefano Rimoldi

Date Deposited:

11 May 2016 13:58

Last Modified:

01 Aug 2016 02:30

Publisher DOI:

10.1097/HCO.0000000000000192

PubMed ID:

26049388

BORIS DOI:

10.7892/boris.76417

URI:

https://boris.unibe.ch/id/eprint/76417

Actions (login required)

Edit item Edit item
Provide Feedback