Effects of microbeam radiation therapy on normal and tumoral blood vessels

Bouchet, Audrey Michele; Serduc, Raphäel; Laissue, Jean Albert; Djonov, Valentin (2015). Effects of microbeam radiation therapy on normal and tumoral blood vessels. Physica medica, 31(6), pp. 634-641. Elsevier 10.1016/j.ejmp.2015.04.014

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Microbeam radiation therapy (MRT) is a new form of preclinical radiotherapy using quasi-parallel arrays of synchrotron X-ray microbeams. While the deposition of several hundred Grays in the microbeam paths, the normal brain tissues presents a high tolerance which is accompanied by the permanence of apparently normal vessels. Conversely, the efficiency of MRT on tumor growth control is thought to be related to a preferential damaging of tumor blood vessels. The high resistance of the healthy vascular network was demonstrated in different animal models by in vivo biphoton microscopy, magnetic resonance imaging, and histological studies. While a transient increase in permeability was shown, the structure of the vessels remained intact. The use of a chick chorioallantoic membrane at different stages of development showed that the damages induced by microbeams depend on vessel maturation. In vivo and ultrastructural observations showed negligible effects of microbeams on the mature vasculature at late stages of development; nevertheless a complete destruction of the immature capillary plexus was found in the microbeam paths. The use of MRT in rodent models revealed a preferential effect on tumor vessels. Although no major modification was observed in the vasculature of normal brain tissue, tumors showed a denudation of capillaries accompanied by transient increased permeability followed by reduced tumor perfusion and finally, a decrease in number of tumor vessels. Thus, MRT is a very promising treatment strategy with pronounced tumor control effects most likely based on the anti-vascular effects of MRT.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy

UniBE Contributor:

Bouchet, Audrey Michele and Djonov, Valentin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1724-191X

Publisher:

Elsevier

Language:

English

Submitter:

Ruslan Hlushchuk

Date Deposited:

08 Mar 2016 14:43

Last Modified:

10 Mar 2016 06:06

Publisher DOI:

10.1016/j.ejmp.2015.04.014

PubMed ID:

26004351

Uncontrolled Keywords:

Healthy tissue; Microbeam radiation therapy; Tumor; Vessels

BORIS DOI:

10.7892/boris.76431

URI:

https://boris.unibe.ch/id/eprint/76431

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