Multibranched acquired periungual fibrokeratomas with confounding histopathologic findings resembling papillomavirus infection: a report of two cases

Göktay, Fatih; Altan, Zeynep Müeyyen; Haras, Zeynep Büşra; Güneş, Pembegül; Yaşar, Şirin; Aytekin, Sema; Haneke, Eckart (2015). Multibranched acquired periungual fibrokeratomas with confounding histopathologic findings resembling papillomavirus infection: a report of two cases. Journal of cutaneous pathology, 42(9), pp. 652-656. Wiley-Blackwell 10.1111/cup.12497

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Acquired periungual fibrokeratomas are benign fibrous tissue tumors and are considered as the topographical variant of acquired digital fibrokeratoma. They usually present as solitary tumors. In some instance, the entity may appear in multibranched fashion. The main histopathologic features consist of acanthosis, thick collagen bundles mainly oriented in a vertical axis forming a central core, and numerous proliferating fibroblasts. In this article, we present two cases of acquired multibranched periungual fibrokeratoma and depict their varying clinical features over time. Binucleation and perinuclear halos of keratinocytes mimicking human papillomavirus (HPV) infection were detected microscopically, but there was no reactivity with HPV immunostaining. In context, anti-HPV immunostaining may be helpful in the differentiation of fibrokeratomas from HPV infection. On the other hand, it should be kept in mind that these histopathologic findings may be found in acral biopsies independent of viral effects.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Haneke, Eckart

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0303-6987

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Sandra Nyffenegger

Date Deposited:

14 Mar 2016 10:13

Last Modified:

09 Nov 2016 16:07

Publisher DOI:

10.1111/cup.12497

PubMed ID:

25924785

Uncontrolled Keywords:

HPV; fibrous tissue neoplasm; immunohistochemistry; nail disease

BORIS DOI:

10.7892/boris.76602

URI:

https://boris.unibe.ch/id/eprint/76602

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