Wiedenmann, Nicole E; Bucher, Sabine; Hentschel, Michael; Mix, Michael; Vach, Werner; Bittner, Martin-Immanuel; Nestle, Ursula; Pfeiffer, Jens; Weber, Wolfgang A; Grosu, Anca L (2015). Serial [18F]-fluoromisonidazole PET during radiochemotherapy for locally advanced head and neck cancer and its correlation with outcome. Radiotherapy and oncology, 117(1), pp. 113-117. Elsevier 10.1016/j.radonc.2015.09.015
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Serial [18F]-fluoromisonidazole PET during radiochemotherapy for locally advanced head and neck cancer and its correlation with outcome.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (993kB) |
PURPOSE
The aim was to assess changes of tumour hypoxia during primary radiochemotherapy (RCT) for head and neck cancer (HNC) and to evaluate their relationship with treatment outcome.
MATERIAL AND METHODS
Hypoxia was assessed by FMISO-PET in weeks 0, 2 and 5 of RCT. The tumour volume (TV) was determined using FDG-PET/MRI/CT co-registered images. The level of hypoxia was quantified on FMISO-PET as TBRmax (SUVmaxTV/SUVmean background). The hypoxic subvolume (HSV) was defined as TV that showed FMISO uptake ⩾1.4 times blood pool activity.
RESULTS
Sixteen consecutive patients (T3-4, N+, M0) were included (mean follow-up 31, median 44months). Mean TBRmax decreased significantly (p<0.05) from 1.94 to 1.57 (week 2) and 1.27 (week 5). Mean HSV in week 2 and week 5 (HSV2=5.8ml, HSV3=0.3ml) were significantly (p<0.05) smaller than at baseline (HSV1=15.8ml). Kaplan-Meier plots of local recurrence free survival stratified at the median TBRmax showed superior local control for less hypoxic tumours, the difference being significant at baseline and after 2weeks (p=0.031, p=0.016).
CONCLUSIONS
FMISO-PET documented that in most HNC reoxygenation starts early during RCT and is correlated with better outcome.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine |
UniBE Contributor: |
Hentschel, Michael |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0167-8140 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Franziska Nicoletti |
Date Deposited: |
26 Feb 2016 15:42 |
Last Modified: |
05 Dec 2022 14:52 |
Publisher DOI: |
10.1016/j.radonc.2015.09.015 |
PubMed ID: |
26432067 |
Uncontrolled Keywords: |
18F-MISO; Head and neck cancer; Hypoxia; PET; Radiochemotherapy |
BORIS DOI: |
10.7892/boris.76686 |
URI: |
https://boris.unibe.ch/id/eprint/76686 |
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