Serial [18F]-fluoromisonidazole PET during radiochemotherapy for locally advanced head and neck cancer and its correlation with outcome.

Wiedenmann, Nicole E; Bucher, Sabine; Hentschel, Michael; Mix, Michael; Vach, Werner; Bittner, Martin-Immanuel; Nestle, Ursula; Pfeiffer, Jens; Weber, Wolfgang A; Grosu, Anca L (2015). Serial [18F]-fluoromisonidazole PET during radiochemotherapy for locally advanced head and neck cancer and its correlation with outcome. Radiotherapy and oncology, 117(1), pp. 113-117. Elsevier 10.1016/j.radonc.2015.09.015

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PURPOSE The aim was to assess changes of tumour hypoxia during primary radiochemotherapy (RCT) for head and neck cancer (HNC) and to evaluate their relationship with treatment outcome. MATERIAL AND METHODS Hypoxia was assessed by FMISO-PET in weeks 0, 2 and 5 of RCT. The tumour volume (TV) was determined using FDG-PET/MRI/CT co-registered images. The level of hypoxia was quantified on FMISO-PET as TBRmax (SUVmaxTV/SUVmean background). The hypoxic subvolume (HSV) was defined as TV that showed FMISO uptake ⩾1.4 times blood pool activity. RESULTS Sixteen consecutive patients (T3-4, N+, M0) were included (mean follow-up 31, median 44months). Mean TBRmax decreased significantly (p<0.05) from 1.94 to 1.57 (week 2) and 1.27 (week 5). Mean HSV in week 2 and week 5 (HSV2=5.8ml, HSV3=0.3ml) were significantly (p<0.05) smaller than at baseline (HSV1=15.8ml). Kaplan-Meier plots of local recurrence free survival stratified at the median TBRmax showed superior local control for less hypoxic tumours, the difference being significant at baseline and after 2weeks (p=0.031, p=0.016). CONCLUSIONS FMISO-PET documented that in most HNC reoxygenation starts early during RCT and is correlated with better outcome.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Hentschel, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0167-8140

Publisher:

Elsevier

Language:

English

Submitter:

Franziska Nicoletti

Date Deposited:

26 Feb 2016 15:42

Last Modified:

20 Mar 2018 13:23

Publisher DOI:

10.1016/j.radonc.2015.09.015

PubMed ID:

26432067

Uncontrolled Keywords:

18F-MISO; Head and neck cancer; Hypoxia; PET; Radiochemotherapy

BORIS DOI:

10.7892/boris.76686

URI:

https://boris.unibe.ch/id/eprint/76686

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