Chiovaro, Francesca; Chiquet-Ehrismann, Ruth; Chiquet, Matthias (2015). Transcriptional regulation of tenascin genes. Cell adhesion & migration, 9(1-2), pp. 34-47. Landes Bioscience 10.1080/19336918.2015.1008333
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Extracellular matrix proteins of the tenascin family resemble each other in their domain structure, and also share functions in modulating cell adhesion and cellular responses to growth factors. Despite these common features, the 4 vertebrate tenascins exhibit vastly different expression patterns. Tenascin-R is specific to the central nervous system. Tenascin-C is an "oncofetal" protein controlled by many stimuli (growth factors, cytokines, mechanical stress), but with restricted occurrence in space and time. In contrast, tenascin-X is a constituitive component of connective tissues, and its level is barely affected by external factors. Finally, the expression of tenascin-W is similar to that of tenascin-C but even more limited. In accordance with their highly regulated expression, the promoters of the tenascin-C and -W genes contain TATA boxes, whereas those of the other 2 tenascins do not. This article summarizes what is currently known about the complex transcriptional regulation of the 4 tenascin genes in development and disease.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics |
UniBE Contributor: |
Chiquet, Matthias |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1933-6918 |
Publisher: |
Landes Bioscience |
Language: |
English |
Submitter: |
Eveline Carmen Schuler |
Date Deposited: |
23 Feb 2016 16:28 |
Last Modified: |
05 Dec 2022 14:52 |
Publisher DOI: |
10.1080/19336918.2015.1008333 |
PubMed ID: |
25793574 |
Uncontrolled Keywords: |
AKT, v-akt murine thymoma viral oncogene homolog ALK, anaplastic lymphoma kinase AP-1, activator protein-1 ATF, activating transcription factor BMP, bone morphogenetic protein CBP, CREB binding protein CREB, cAMP response element-binding protein CREB-RP, CREB-related protein CYP21A2, cytochrome P450 family 21 subfamily A polypeptide 2 ChIP, chromatin immunoprecipitation EBS, Ets binding site ECM, extracellular matrix EGF, epidermal growth factor ERK1/2, extracellular signal-regulated kinase 1/2 ETS, E26 transformation-specific EWS-ETS, Ewing sarcoma-Ets fusion protein Evx1, even skipped homeobox 1 FGF, fibroblast growth factor HBS, homeodomain binding sequence IL, interleukin ILK, integrin-linked kinase JAK, Janus kinase JNK, c-Jun N-terminal kinase MHCIII, major histocompatibility complex class III MKL1, megakaryoblastic leukemia-1 NFκB, nuclear factor kappa B NGF, nerve growth factor; NFAT, nuclear factor of activated T-cells OTX2, orthodenticle homolog 2 PDGF, platelet-derived growth factor PI3K, phosphatidylinositol 3-kinase POU3F2, POU domain class 3 transcription factor 2 PRRX1, paired-related homeobox 1 RBPJk, recombining binding protein suppressor of hairless ROCK, Rho-associated, coiled-coil-containing protein kinase RhoA, ras homolog gene family member A SAP, SAF-A/B, Acinus, and PIAS SCX, scleraxix SEAP, secreted alkaline phosphatase SMAD, small body size - mothers against decapentaplegic SOX4, sex determining region Y-box 4 SRE, serum response element SRF, serum response factor STAT, signal transducer and activator of transcription TGF-β, transforming growth factor-β TNC, tenascin-C TNF-α, tumor necrosis factor-α TNR, tenascin-R TNW, tenascin-W TNX, tenascin-X TSS, transcription start site UTR, untranslated region WNT, wingless-related integration site cancer cytokine development extracellular matrix gene promoter gene regulation glucocorticoid growth factor homeobox gene matricellular mechanical stress miR, micro RNA p38 MAPK, p38 mitogen activated protein kinase tenascin transcription factor |
BORIS DOI: |
10.7892/boris.76771 |
URI: |
https://boris.unibe.ch/id/eprint/76771 |
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