Multiple functions of gingival and mucoperiosteal fibroblasts in oral wound healing and repair

Chiquet, Matthias; Katsaros, Christos; Kletsas, Dimitris (2015). Multiple functions of gingival and mucoperiosteal fibroblasts in oral wound healing and repair. Periodontology 2000, 68(1), pp. 21-40. Blackwell 10.1111/prd.12076

[img] Text
Multiple functions of gingival.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (349kB) | Request a copy
[img]
Preview
Text
Chiquet_accepted_manuscript.pdf - Accepted Version
Available under License Publisher holds Copyright.

Download (340kB) | Preview

Fibroblasts are cells of mesenchymal origin. They are responsible for the production of most extracellular matrix in connective tissues and are essential for wound healing and repair. In recent years, it has become clear that fibroblasts from different tissues have various distinct traits. Moreover, wounds in the oral cavity heal under very special environmental conditions compared with skin wounds. Here, we reviewed the current literature on the various interconnected functions of gingival and mucoperiosteal fibroblasts during the repair of oral wounds. The MEDLINE database was searched with the following terms: (gingival OR mucoperiosteal) AND fibroblast AND (wound healing OR repair). The data gathered were used to compare oral fibroblasts with fibroblasts from other tissues in terms of their regulation and function during wound healing. Specifically, we sought answers to the following questions: (i) what is the role of oral fibroblasts in the inflammatory response in acute wounds; (ii) how do growth factors control the function of oral fibroblasts during wound healing; (iii) how do oral fibroblasts produce, remodel and interact with extracellular matrix in healing wounds; (iv) how do oral fibroblasts respond to mechanical stress; and (v) how does aging affect the fetal-like responses and functions of oral fibroblasts? The current state of research indicates that oral fibroblasts possess unique characteristics and tightly controlled specific functions in wound healing and repair. This information is essential for developing new strategies to control the intraoral wound-healing processes of the individual patient.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics

UniBE Contributor:

Chiquet, Matthias and Katsaros, Christos

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0906-6713

Publisher:

Blackwell

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

08 Mar 2016 15:35

Last Modified:

11 Sep 2017 09:02

Publisher DOI:

10.1111/prd.12076

PubMed ID:

25867977

BORIS DOI:

10.7892/boris.76776

URI:

https://boris.unibe.ch/id/eprint/76776

Actions (login required)

Edit item Edit item
Provide Feedback