EEG microstate analysis in drug-naive patients with panic disorder

Kikuchi, Mitsuru; König, Thomas; Munesue, Toshio; Hanaoka, Akira; Strik, Werner; Dierks, Thomas; Koshino, Yoshifumi; Minabea, Yoshio (2011). EEG microstate analysis in drug-naive patients with panic disorder. PLoS ONE, 6(7), e22912. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0022912

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Patients with panic disorder (PD) have a bias to respond to normal stimuli in a fearful way. This may be due to the preactivation of fear-associated networks prior to stimulus perception. Based on EEG, we investigated the difference between patients with PD and normal controls in resting state activity using features of transiently stable brain states (microstates). EEGs from 18 drug-naive patients and 18 healthy controls were analyzed. Microstate analysis showed that one class of microstates (with a right-anterior to left-posterior orientation of the mapped field) displayed longer durations and covered more of the total time in the patients than controls. Another microstate class (with a symmetric, anterior-posterior orientation) was observed less frequently in the patients compared to controls. The observation that selected microstate classes differ between patients with PD and controls suggests that specific brain functions are altered already during resting condition. The altered resting state may be the starting point of the observed dysfunctional processing of phobic stimuli.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management

UniBE Contributor:

König, Thomas; Strik, Werner and Dierks, Thomas

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:22

Last Modified:

05 Dec 2014 08:07

Publisher DOI:

10.1371/journal.pone.0022912

PubMed ID:

21829554

Web of Science ID:

000293286500050

BORIS DOI:

10.7892/boris.7684

URI:

https://boris.unibe.ch/id/eprint/7684 (FactScience: 213000)

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