Comparative dendritic cell biology of veterinary mammals.

Summerfield, Artur; Auray, Gael; Ricklin, Meret (2015). Comparative dendritic cell biology of veterinary mammals. Annual Review of Animal Biosciences, 3, pp. 533-557. Annual Reviews 10.1146/annurev-animal-022114-111009

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Dendritic cells (DC) have a main function in innate immunity in that they sense infections and environmental antigens at the skin and mucosal surfaces and thereby critically influence decisions about immune activation or tolerance. As professional antigen-presenting cells, they are essential for induction of adaptive immune responses. Consequently, knowledge on this cell type is required to understand the immune systems of veterinary mammals, including cattle, sheep, pigs, dogs, cats, and horses. Recent ontogenic studies define bona fide DC as an independent lineage of hematopoietic cells originating from a common precursor. Distinct transcription factors control the development into the two subsets of classical DC and plasmacytoid DC. These DC subsets express a distinguishable transcriptome, which differs from that of monocyte-derived DC. Using a comparative approach based on phenotype and function, this review attempts to classify DC of veterinary mammals and to describe important knowledge gaps.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Summerfield, Artur; Auray, Gael and Ricklin, Meret

Subjects:

600 Technology > 630 Agriculture

ISSN:

2165-8110

Publisher:

Annual Reviews

Language:

English

Submitter:

Barbara Gautschi-Steffen

Date Deposited:

02 Mar 2016 11:40

Last Modified:

02 Mar 2016 11:40

Publisher DOI:

10.1146/annurev-animal-022114-111009

PubMed ID:

25387110

Uncontrolled Keywords:

bovine canine dendritic cells equine feline macrophages monocytes ovine porcine

URI:

https://boris.unibe.ch/id/eprint/76855

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