Chronological Order of Appearance of Extraintestinal Manifestations Relative to the Time of IBD Diagnosis in the Swiss Inflammatory Bowel Disease Cohort.

Vavricka, Stephan R; Rogler, Gerhard; Gantenbein, Claudine; Spoerri, Muriel; Prinz Vavricka, Mareike; Navarini, Alexander A; French, Lars E; Safroneeva, Ekaterina; Fournier, Nicolas; Straumann, Alex; Froehlich, Florian; Fried, Michael; Michetti, Pierre; Seibold, Frank Werner; Lakatos, Peter L; Peyrin-Biroulet, Laurent; Schoepfer, Alain M (2015). Chronological Order of Appearance of Extraintestinal Manifestations Relative to the Time of IBD Diagnosis in the Swiss Inflammatory Bowel Disease Cohort. Inflammatory bowel diseases, 21(8), pp. 1794-1800. Lippincott Williams & Wilkins 10.1097/MIB.0000000000000429

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BACKGROUND

Data evaluating the chronological order of appearance of extraintestinal manifestations (EIMs) relative to the time of inflammatory bowel disease (IBD) diagnosis is currently lacking. We aimed to assess the type, frequency, and chronological order of appearance of EIMs in patients with IBD.

METHODS

Data from the Swiss Inflammatory Bowel Disease Cohort Study were analyzed.

RESULTS

The data on 1249 patients were analyzed (49.8% female, median age: 40 [interquartile range, 30-51 yr], 735 [58.8%] with Crohn's disease, 483 [38.7%] with ulcerative colitis, and 31 [2.5%] with indeterminate colitis). A total of 366 patients presented with EIMs (29.3%). Of those, 63.4% presented with 1, 26.5% with 2, 4.9% with 3, 2.5% with 4, and 2.7% with 5 EIMs during their lifetime. Patients presented with the following diseases as first EIMs: peripheral arthritis 70.0%, aphthous stomatitis 21.6%, axial arthropathy/ankylosing spondylitis 16.4%, uveitis 13.7%, erythema nodosum 12.6%, primary sclerosing cholangitis 6.6%, pyoderma gangrenosum 4.9%, and psoriasis 2.7%. In 25.8% of cases, patients presented with their first EIM before IBD was diagnosed (median time 5 mo before IBD diagnosis: range, 0-25 mo), and in 74.2% of cases, the first EIM manifested itself after IBD diagnosis (median: 92 mo; range, 29-183 mo).

CONCLUSIONS

In one quarter of patients with IBD, EIMs appeared before the time of IBD diagnosis. Occurrence of EIMs should prompt physicians to look for potential underlying IBD.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Safroneeva, Ekaterina and Seibold, Frank Werner

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1078-0998

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

09 Feb 2016 15:47

Last Modified:

08 Sep 2017 10:59

Publisher DOI:

10.1097/MIB.0000000000000429

PubMed ID:

26020601

BORIS DOI:

10.7892/boris.76878

URI:

https://boris.unibe.ch/id/eprint/76878

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