Effects of transcranial direct current stimulation (tDCS) on behaviour and electrophysiology of language production

Wirth, Miranka; Rahman, Rasha Abdel; Kuenecke, Janina; König, Thomas; Horn, Helge; Sommer, Werner; Dierks, Thomas (2011). Effects of transcranial direct current stimulation (tDCS) on behaviour and electrophysiology of language production. Neuropsychologia, 49(14), pp. 3989-3998. Oxford: Elsevier 10.1016/j.neuropsychologia.2011.10.015

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Excitatory anodal transcranial direct current stimulation (A-tDCS) over the left dorsal prefrontal cortex (DPFC) has been shown to improve language production. The present study examined neurophysiological underpinnings of this effect. In a single-blinded within-subject design, we traced effects of A-tDCS compared to sham stimulation over the left DPFC using electrophysiological and behavioural correlates during overt picture naming. Online effects were examined during A-tDCS by employing the semantic interference (SI-)Effect – a marker that denotes the functional integrity of the language system. The behavioural SI-Effect was found to be reduced, whereas the electrophysiological SI-Effect was enhanced over left compared to right temporal scalp-electrode sites. This modulation is suggested to reflect a superior tuning of neural responses within language-related generators. After -(offline) effects of A-tDCS were detected in the delta frequency band, a marker of neural inhibition. After A-tDCS there was a reduction in delta activity during picture naming and the resting state, interpreted to indicate neural disinhibition. Together, these findings demonstrate electrophysiological modulations induced by A-tDCS of the left DPFC. They suggest that A-tDCS is capable of enhancing neural processes during and after application. The present functional and oscillatory neural markers could detect positive effects of prefrontal A-tDCS, which could be of use in the neuro-rehabilitation of frontal language functions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > UPD Murtenstrasse

UniBE Contributor:

Wirth, Miranka; König, Thomas; Horn, Helge Joachim and Dierks, Thomas

ISSN:

0028-3932

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:22

Last Modified:

29 Jan 2015 07:17

Publisher DOI:

10.1016/j.neuropsychologia.2011.10.015

PubMed ID:

22044650

Web of Science ID:

000298527700020

BORIS DOI:

10.7892/boris.7688

URI:

https://boris.unibe.ch/id/eprint/7688 (FactScience: 213005)

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