Acute mental stress and hemostasis: When physiology becomes vascular harm

von Känel, Roland (2015). Acute mental stress and hemostasis: When physiology becomes vascular harm. Thrombosis research, 135(Suppl 1), S52-S55. Elsevier 10.1016/S0049-3848(15)50444-1

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Stress-induced activation of the sympathoadrenal medullary system activates both the coagulation and fibrinolysis system resulting in net hypercoagulability. The evolutionary interpretation of this physiology is that stress-hypercoagulability protects a healthy organism from excess bleeding should injury occur in fight-or-flight situations. In turn, acute mental stress, negative emotions and psychological trauma also are triggering factors of atherothrombotic events and possibly of venous thromboembolism. Individuals with pre-existent atherosclerosis and impaired endothelial anticoagulant function are the most vulnerable to experience onset of acute coronary events within two hours of intense emotions. A range of sociodemographic and psychosocial factors (e.g., chronic stress and negative affect) might critically intensify and prolong stress-induced hypercoagulability. In contrast, several pharmacological compounds, dietary flavanoids, and positive affect mitigate the acute prothrombotic stress response. Studies are needed to investigate whether attenuation of stress-hypercoagulability through medications and biobehavioral interventions reduce the risk of thrombotic incidents in at-risk populations.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie

UniBE Contributor:

von Känel, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0049-3848

Publisher:

Elsevier

Language:

English

Submitter:

Romina Theiler

Date Deposited:

16 Mar 2016 14:41

Last Modified:

02 May 2016 10:56

Publisher DOI:

10.1016/S0049-3848(15)50444-1

PubMed ID:

25903538

Uncontrolled Keywords:

Blood coagulation; Cardiovascular disease; Fibrinolysis; Psychological stress; Risk factor; Thrombosis

BORIS DOI:

10.7892/boris.77018

URI:

https://boris.unibe.ch/id/eprint/77018

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