Surgery for Stage IIIA Non-Small-cell Lung Cancer: Lack of Predictive and Prognostic Factors Identifying Any Subgroup of Patients Benefiting From It.

Jeremić, Branislav; Casas, Francesc; Dubinsky, Pavol; Gomez-Caamano, Antonio; Cihoric, Nikola; Videtic, Greg (2016). Surgery for Stage IIIA Non-Small-cell Lung Cancer: Lack of Predictive and Prognostic Factors Identifying Any Subgroup of Patients Benefiting From It. Clinical lung cancer, 17(2), pp. 107-112. Elsevier 10.1016/j.cllc.2015.11.001

[img] Text
1-s2.0-S152573041500265X-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (210kB) | Request a copy

Although a trimodality regimen for patients with stage IIIA/pN2 non-small-cell lung cancer (NSCLC) has been variably used owing to limited evidence for its benefits, it remains unknown whether any patient subgroup actually receives benefit from such an approach. To explore this question, the published data were reviewed from 1990 to 2015 to identify the possible predictors and prognosticators in this setting. Overall survival was the endpoint of our study. Of 27 identified studies, none had studied the predictors of improved outcomes with trimodality treatment. Of the potential patient- and tumor-related prognosticators, age, gender, and histologic type were the most frequently formally explored. However, none of the 3 was found to influence overall survival. The most prominent finding of the present review was the substantial lack of data supporting a trimodality treatment approach in any patient subgroup. As demonstrated in completed prospective randomized studies, the use of surgery for stage IIIA NSCLC should be limited to well-defined clinical trials.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Cihoric, Nikola

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1525-7304

Publisher:

Elsevier

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

25 Apr 2016 14:39

Last Modified:

15 Sep 2017 14:20

Publisher DOI:

10.1016/j.cllc.2015.11.001

PubMed ID:

26683387

Uncontrolled Keywords:

NSCLC, Predictive factors, Prognostic factors, Trimodality therapy, pN2 disease

BORIS DOI:

10.7892/boris.77035

URI:

https://boris.unibe.ch/id/eprint/77035

Actions (login required)

Edit item Edit item
Provide Feedback