Hypothalamic feedforward inhibition of thalamocortical network controls arousal and consciousness.

Gutierrez Herrera, Carolina; Cadavieco, Marta Carus; Jego, Sonia; Ponomarenko, Alexey; Korotkova, Tatiana; Adamantidis, Antoine Roger (2016). Hypothalamic feedforward inhibition of thalamocortical network controls arousal and consciousness. Nature neuroscience, 19(2), pp. 290-298. Nature America 10.1038/nn.4209

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During non-rapid eye movement (NREM) sleep, synchronous synaptic activity in the thalamocortical network generates predominantly low-frequency oscillations (<4 Hz) that are modulated by inhibitory inputs from the thalamic reticular nucleus (TRN). Whether TRN cells integrate sleep-wake signals from subcortical circuits remains unclear. We found that GABA neurons from the lateral hypothalamus (LHGABA) exert a strong inhibitory control over TRN GABA neurons (TRNGABA). We found that optogenetic activation of this circuit recapitulated state-dependent changes of TRN neuron activity in behaving mice and induced rapid arousal during NREM, but not REM, sleep. During deep anesthesia, activation of this circuit induced sustained cortical arousal. In contrast, optogenetic silencing of LHGABA-TRNGABA transmission increased the duration of NREM sleep and amplitude of delta (1-4 Hz) oscillations. Collectively, these results demonstrate that TRN cells integrate subcortical arousal inputs selectively during NREM sleep and may participate in sleep intensity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Gutierrez Herrera, Carolina and Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1097-6256

Publisher:

Nature America

Language:

English

Submitter:

Romina Theiler

Date Deposited:

31 Mar 2016 09:05

Last Modified:

02 May 2016 10:17

Publisher DOI:

10.1038/nn.4209

PubMed ID:

26691833

BORIS DOI:

10.7892/boris.77036

URI:

https://boris.unibe.ch/id/eprint/77036

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