Distinct roles of cortical and pallidal β and γ frequencies in hemiparkinsonian and dyskinetic rats.

Salvadè, Agnese; D'Angelo, Vincenza; Di Giovanni, Giuseppe; Tinkhauser, Gerd; Sancesario, Giuseppe; Städler, Claudio; Möller, Jens C; Stefani, Alessandro; Kaelin, Alain; Galati, Salvatore (2016). Distinct roles of cortical and pallidal β and γ frequencies in hemiparkinsonian and dyskinetic rats. Experimental neurology, 275(Pt 1), pp. 199-208. Elsevier 10.1016/j.expneurol.2015.11.005

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Enhanced β band (βB) activity, which is suppressed by levodopa (LD) treatment, has been demonstrated within the basal ganglia (BG) of Parkinson's disease (PD) patients. However, some data suggest that Parkinsonian symptoms are not directly related to this brain frequency and therefore, its causative role remains questionable. A less explored phenomenon is the link between the γ band (γB) and PD phenomenology. Here, we monitored the development of the oscillatory activity during chronic LD depletion and LD treatment in Parkinsonian and levodopa-induced dyskinesia (LID) in rats. We found a significant and bilateral power increase in the high βB frequencies (20-30Hz) within the first 10days after 6-hydroxydopamine (6-OHDA) lesion, which was in accordance with a significant depletion of dopaminergic fibers in the striatum. We also observed a clear-cut γB increase during LD treatment. The development of LID was characterized by a slight increase in the cumulative power of βB accompanied by a large augmentation in the γB frequency (60-80Hz). This latter effect reached a plateau in the frontal cortex bilaterally and the left globus pallidus after the second week of LD treatment. Our data suggest that the βB parallels the emergence of Parkinsonian signs and can be taken as a predictive sign of DA depletion, matching TH-staining reduction. On the other hand, the γB is strictly correlated to the development of LID. LD treatment had an opposite effect on βB and γB, respectively.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Tinkhauser, Gerd and Kaelin, Alain

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0014-4886

Publisher:

Elsevier

Language:

English

Submitter:

Romina Theiler

Date Deposited:

22 Mar 2016 16:57

Last Modified:

02 May 2016 10:26

Publisher DOI:

10.1016/j.expneurol.2015.11.005

PubMed ID:

26571194

Uncontrolled Keywords:

Beta band oscillation; Local field potentials; Parkinson's disease; Rat animal model; Recordings in freely moving animals

BORIS DOI:

10.7892/boris.77072

URI:

https://boris.unibe.ch/id/eprint/77072

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