Scheepers, Jacobus De Wet; Malan, Leoné; de Kock, Andrea; Malan, Nicolaas Theodor; Cockeran, Marike; von Känel, Roland (2016). Hypercoagulation and hyperkinetic blood pressure indicative of physiological loss-of-control despite behavioural control in Africans: The SABPA study. Blood pressure, 25(4), pp. 1-9. Taylor & Francis 10.3109/08037051.2015.1131432
Full text not available from this repository.OBJECTIVES
A dissociation between behavioural (in-control) and physiological parameters (indicating loss-of-control) is associated with cardiovascular risk in defensive coping (DefS) Africans. We evaluated relationships between DefS, sub-clinical atherosclerosis, low-grade inflammation and hypercoagulation in a bi-ethnic sex cohort.
METHODS
Black (Africans) and white Africans (Caucasians) (n = 375; aged 44.6 ± 9.7 years) were included. Ambulatory BP, vascular structure (left carotid cross-sectional wall area (L-CSWA) and plaque counts), and markers of coagulation and inflammation were quantified. Ethnicity/coping style interaction was revealed only in DefS participants.
RESULTS
A hypertensive state, less plaque, low-grade inflammation, and hypercoagulation were more prevalent in DefS Africans (27-84%) than DefS Caucasians (18-41%). Regression analyses demonstrated associations between L-CSWA and 24 hour systolic BP (R(2) = 0.38; β = 0.78; p < 0.05) in DefS African men but not in DefS African women or Caucasians. No associations between L-CSWA and coagulation markers were evident.
CONCLUSION
Novel findings revealed hypercoagulation, low-grade inflammation and hyperkinetic BP (physiological loss-of-control responses) in DefS African men. Coupled to a self-reported in-control DefS behavioural profile, this reflects dissociation between behaviour and physiology. It may explain changes in vascular structure, increasing cerebrovascular disease risk in a state of hyper-vigilant coping.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie |
UniBE Contributor: |
von Känel, Roland |
ISSN: |
0803-7051 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Romina Theiler |
Date Deposited: |
10 May 2016 15:39 |
Last Modified: |
05 Dec 2022 14:52 |
Publisher DOI: |
10.3109/08037051.2015.1131432 |
PubMed ID: |
26806201 |
Uncontrolled Keywords: |
Africans; Coagulation; Coping; Dissociation; Structural vascular disease; Vascular remodelling |
URI: |
https://boris.unibe.ch/id/eprint/77076 |
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