Hypermagnesemia is a strong independent risk factor for mortality in critically ill patients: results from a cross-sectional study.

Haider, Dominik; Lindner, Gregor; Ahmad, Sufian; Sauter, Thomas; Wolzt, Michael; Leichtle, Alexander Benedikt; Fiedler, Martin; Exadaktylos, Aristomenis; Fuhrmann, Valentin (2015). Hypermagnesemia is a strong independent risk factor for mortality in critically ill patients: results from a cross-sectional study. European journal of internal medicine, 26(7), pp. 504-507. Pozzi 10.1016/j.ejim.2015.05.013

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BACKGROUND Patients with electrolyte imbalances or disorders have a high risk of mortality. It is unknown if this finding from sodium or potassium disorders extends to alterations of magnesium levels. METHODS AND PATIENTS In this cross-sectional analysis, all emergency room patients between 2010 and 2011 at the Inselspital Bern, Switzerland, were included. A multivariable logistic regression model was performed to assess the association between magnesium levels and in-hospital mortality up to 28days. RESULTS A total of 22,239 subjects were screened for the study. A total of 5339 patients had plasma magnesium concentrations measured at hospital admission and were included into the analysis. A total of 6.3% of the 352 patients with hypomagnesemia and 36.9% of the 151 patients with hypermagnesemia died. In a multivariate Cox regression model hypermagnesemia (HR 11.6, p<0.001) was a strong independent risk factor for mortality. In these patients diuretic therapy revealed to be protective (HR 0.5, p=0.007). Hypomagnesemia was not associated with mortality (p>0.05). Age was an independent risk factor for mortality (both p<0.001). CONCLUSION The study does demonstrate a possible association between hypermagnesemia measured upon admission in the emergency department, and early in-hospital mortality.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > University Emergency Center
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry

UniBE Contributor:

Haider, Dominik; Lindner, Gregor; Ahmad, Sufian; Sauter, Thomas; Leichtle, Alexander Benedikt; Fiedler, Martin and Exadaktylos, Aristomenis

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0953-6205

Publisher:

Pozzi

Language:

English

Submitter:

Marie-Christine Müller

Date Deposited:

22 Feb 2016 17:12

Last Modified:

10 Mar 2016 10:17

Publisher DOI:

10.1016/j.ejim.2015.05.013

PubMed ID:

26049918

Uncontrolled Keywords:

Critically ill; Emergency room; Hypermagnesemia; Hypomagnesemia; Mortality; Normomagnesemia

BORIS DOI:

10.7892/boris.77166

URI:

https://boris.unibe.ch/id/eprint/77166

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