Ventilation/perfusion SPECT/CT in patients with pulmonary emphysema. Evaluation of software-based analysing

Schreiter, V; Steffen, I; Huebner, H; Bredow, J; Heimann, U; Kroencke, T J; Pöllinger, Alexander; Doellinger, F; Buchert, R; Hamm, B; Brenner, W; Schreiter, N F (2015). Ventilation/perfusion SPECT/CT in patients with pulmonary emphysema. Evaluation of software-based analysing. Nuklearmedizin / Nuclear medicine, 54(1), pp. 31-35. Schattauer 10.3413/Nukmed-0704-14-10

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UNLABELLED The purpose of this study was to evaluate the reproducibility of a new software based analysing system for ventilation/perfusion single-photon emission computed tomography/computed tomography (V/P SPECT/CT) in patients with pulmonary emphysema and to compare it to the visual interpretation. PATIENTS, MATERIAL AND METHODS 19 patients (mean age: 68.1 years) with pulmonary emphysema who underwent V/P SPECT/CT were included. Data were analysed by two independent observers in visual interpretation (VI) and by software based analysis system (SBAS). SBAS PMOD version 3.4 (Technologies Ltd, Zurich, Switzerland) was used to assess counts and volume per lung lobe/per lung and to calculate the count density per lung, lobe ratio of counts and ratio of count density. VI was performed using a visual scale to assess the mean counts per lung lobe. Interobserver variability and association for SBAS and VI were analysed using Spearman's rho correlation coefficient. RESULTS Interobserver agreement correlated highly in perfusion (rho: 0.982, 0.957, 0.90, 0.979) and ventilation (rho: 0.972, 0.924, 0.941, 0.936) for count/count density per lobe and ratio of counts/count density in SBAS. Interobserver agreement correlated clearly for perfusion (rho: 0.655) and weakly for ventilation (rho: 0.458) in VI. CONCLUSIONS SBAS provides more reproducible measures than VI for the relative tracer uptake in V/P SPECT/CTs in patients with pulmonary emphysema. However, SBAS has to be improved for routine clinical use.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Pöllinger, Alexander


600 Technology > 610 Medicine & health








Aisha Stefania Mzinga

Date Deposited:

17 Mar 2016 10:47

Last Modified:

30 Mar 2016 13:56

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

V/P SPECT/CT pulmonary emphysema software-based analysing


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