A new model of interactive effects of alcohol and high-fat diet on hepatic fibrosis

Gäbele, Erwin; Dostert, Karin; Dorn, Christoph; Patsenker, Eleonora; Stickel, Felix; Hellerbrand, Claus (2011). A new model of interactive effects of alcohol and high-fat diet on hepatic fibrosis. Alcoholism: clinical and experimental research, 35(7), pp. 1361-7. Oxford: Wiley-Blackwell 10.1111/j.1530-0277.2011.01472.x

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Alcoholic steatohepatitis (ASH) and nonalcoholic steatohepatitis (NASH) are the most frequent conditions leading to elevated liver enzymes and liver cirrhosis, respectively, in the Western world. However, despite strong epidemiological evidence for combined effects on the progression of liver injury, the mutual interaction of the pathophysiological mechanisms is incompletely understood. The aim of this study was to establish and analyze an experimental murine model, where we combined chronic alcohol administration with a NASH-inducing high-fat (HF) diet.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Stickel, Felix

ISSN:

0145-6008

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:22

Last Modified:

17 Mar 2015 21:01

Publisher DOI:

10.1111/j.1530-0277.2011.01472.x

PubMed ID:

21463337

Web of Science ID:

000292109500020

URI:

https://boris.unibe.ch/id/eprint/7727 (FactScience: 213053)

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