Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the α4β1-integrin

Martin-Blondel, Guillaume; Pignolet, Béatrice; Tietz, Silvia; Yshii, Lidia; Gebauer, Christina; Périnat, Therese; Van Weddingen, Isabelle; Blatti, Claudia; Engelhardt, Britta; Liblau, Roland (2015). Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the α4β1-integrin. European journal of immunology, 45(12), pp. 3302-3312. Wiley-VCH 10.1002/eji.201545632

Text eji3449.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (1MB)

Although CD8 T cells are key players in neuroinflammation, little is known about their trafficking cues into the central nervous system (CNS). We used a murine model of CNS autoimmunity to define the molecules involved in cytotoxic CD8 T-cell migration into the CNS. Using a panel of mAbs, we here show that the α4β1-integrin is essential for CD8 T-cell interaction with CNS endothelium. We also investigated which α4β1-integrin ligands expressed by endothelial cells are implicated. The blockade of VCAM-1 did not protect against autoimmune encephalomyelitis, and only partly decreased the CD8(+) T-cell infiltration into the CNS. In addition, inhibition of junctional adhesion molecule-B expressed by CNS endothelial cells also decreases CD8 T-cell infiltration. CD8 T cells may use additional and possibly unidentified adhesion molecules to gain access to the CNS.

Interest & Impact

Downloads

4 since deposited on 14 Mar 2016
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item