Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the α4β1-integrin

Martin-Blondel, Guillaume; Pignolet, Béatrice; Tietz, Silvia; Yshii, Lidia; Gebauer, Christina; Périnat, Therese; Van Weddingen, Isabelle; Blatti, Claudia; Engelhardt, Britta; Liblau, Roland (2015). Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the α4β1-integrin. European journal of immunology, 45(12), pp. 3302-3312. Wiley-VCH 10.1002/eji.201545632

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Although CD8 T cells are key players in neuroinflammation, little is known about their trafficking cues into the central nervous system (CNS). We used a murine model of CNS autoimmunity to define the molecules involved in cytotoxic CD8 T-cell migration into the CNS. Using a panel of mAbs, we here show that the α4β1-integrin is essential for CD8 T-cell interaction with CNS endothelium. We also investigated which α4β1-integrin ligands expressed by endothelial cells are implicated. The blockade of VCAM-1 did not protect against autoimmune encephalomyelitis, and only partly decreased the CD8(+) T-cell infiltration into the CNS. In addition, inhibition of junctional adhesion molecule-B expressed by CNS endothelial cells also decreases CD8 T-cell infiltration. CD8 T cells may use additional and possibly unidentified adhesion molecules to gain access to the CNS.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Tietz, Silvia; Périnat, Therese; Blatti, Claudia and Engelhardt, Britta

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0014-2980

Publisher:

Wiley-VCH

Language:

English

Submitter:

Ursula Zingg-Zünd

Date Deposited:

14 Mar 2016 15:15

Last Modified:

16 Mar 2016 08:34

Publisher DOI:

10.1002/eji.201545632

PubMed ID:

26358409

Uncontrolled Keywords:

CD8 T cell; Junctional adhesion molecule-B; Migration; Neuroinflammation; α4β1-Integrin

BORIS DOI:

10.7892/boris.77294

URI:

https://boris.unibe.ch/id/eprint/77294

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