Salient features of the coronary collateral circulation and its clinical relevance

Stoller, Michael; Seiler, Christian (2015). Salient features of the coronary collateral circulation and its clinical relevance. Swiss medical weekly, 145, w14154. EMH Schweizerischer Ärzteverlag 10.4414/smw.2015.14154

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The coronary collateral circulation provides an alternative source of blood supply to myocardium jeopardised by ischaemia. Collaterals enlarge with obstructive coronary artery disease to allow bulk flow, but blood flow deliverable by the native, pre-formed collateral extent can already be sizeable. Genetic determinants contribute significantly to the wide variability observed in both native collateral extent and its capacity to enlarge, and the severity of the coronary stenosis is the most significant environmental determinant for collateral enlargement. The protective effect of a well-developed coronary collateral circulation translates into relevant improvements in all-cause and cardiac mortality in the acute and chronic phases of coronary artery disease, as well as into a reduction of future adverse cardiovascular events.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Stoller, Michael and Seiler, Christian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1424-7860

Publisher:

EMH Schweizerischer Ärzteverlag

Language:

English

Submitter:

Jacques Donzé

Date Deposited:

23 Mar 2016 12:00

Last Modified:

15 Jan 2017 02:04

Publisher DOI:

10.4414/smw.2015.14154

PubMed ID:

26218664

BORIS DOI:

10.7892/boris.77314

URI:

https://boris.unibe.ch/id/eprint/77314

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