Brain barriers: Crosstalk between complex tight junctions and adherens junctions

Tietz, Silvia; Engelhardt, Britta (2015). Brain barriers: Crosstalk between complex tight junctions and adherens junctions. Journal of cell biology, 209(4), pp. 493-506. Rockefeller Institute Press 10.1083/jcb.201412147

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Unique intercellular junctional complexes between the central nervous system (CNS) microvascular endothelial cells and the choroid plexus epithelial cells form the endothelial blood-brain barrier (BBB) and the epithelial blood-cerebrospinal fluid barrier (BCSFB), respectively. These barriers inhibit paracellular diffusion, thereby protecting the CNS from fluctuations in the blood. Studies of brain barrier integrity during development, normal physiology, and disease have focused on BBB and BCSFB tight junctions but not the corresponding endothelial and epithelial adherens junctions. The crosstalk between adherens junctions and tight junctions in maintaining barrier integrity is an understudied area that may represent a promising target for influencing brain barrier function.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Tietz, Silvia and Engelhardt, Britta

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0021-9525

Publisher:

Rockefeller Institute Press

Language:

English

Submitter:

Ursula Zingg-Zünd

Date Deposited:

14 Mar 2016 15:04

Last Modified:

30 May 2016 18:31

Publisher DOI:

10.1083/jcb.201412147

PubMed ID:

26008742

BORIS DOI:

10.7892/boris.77329

URI:

https://boris.unibe.ch/id/eprint/77329

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