Kruger, Philipp; Saffarzadeh, Mona; Weber, Alexander N R; Rieber, Nikolaus; Radsak, Markus; von Bernuth, Horst; Benarafa, Charaf; Roos, Dirk; Skokowa, Julia; Hartl, Dominik (2015). Neutrophils: Between host defence, immune modulation, and tissue injury. PLoS pathogens, 11(3), e1004651. Public Library of Science 10.1371/journal.ppat.1004651
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Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of infection, where they fulfill their life-saving antimicrobial functions. While traditionally regarded as short-lived phagocytes, recent findings on long-term survival, neutrophil extracellular trap (NET) formation, heterogeneity and plasticity, suppressive functions, and tissue injury have expanded our understanding of their diverse role in infection and inflammation. This review summarises our current understanding of neutrophils in host-pathogen interactions and disease involvement, illustrating the versatility and plasticity of the neutrophil, moving between host defence, immune modulation, and tissue damage.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute |
UniBE Contributor: |
Benarafa, Charaf |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1553-7366 |
Publisher: |
Public Library of Science |
Language: |
English |
Submitter: |
Ursula Zingg-Zünd |
Date Deposited: |
22 Feb 2016 17:32 |
Last Modified: |
05 Dec 2022 14:52 |
Publisher DOI: |
10.1371/journal.ppat.1004651 |
PubMed ID: |
25764063 |
BORIS DOI: |
10.7892/boris.77349 |
URI: |
https://boris.unibe.ch/id/eprint/77349 |
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