Racemates revisited: heterochiral assemblies and the example of DL-thalidomide

Hague, David E; Idle, Jeffrey R; Mitchell, Steve C; Smith, Robert L (2011). Racemates revisited: heterochiral assemblies and the example of DL-thalidomide. Xenobiotica, 41(10), pp. 837-43. London: Informa Healthcare 10.3109/00498254.2011.590547

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The existence of racemic compounds, comprised of pairs of opposite enantiomers as discrete molecular entities, has been accepted for over a century. However, their ability to remain as associated dimers when in solution is uncertain, if not generally doubted. In this article, data has been assembled to provide evidence for the presence of intact dimeric heterochiral assemblies in solution and presents DL-thalidomide as a probable example of this phenomenon.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Idle, Jeffrey

ISSN:

0049-8254

Publisher:

Informa Healthcare

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:22

Last Modified:

17 Mar 2015 21:01

Publisher DOI:

10.3109/00498254.2011.590547

PubMed ID:

21726171

Web of Science ID:

000294871300001

URI:

https://boris.unibe.ch/id/eprint/7737 (FactScience: 213063)

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