DTI and VBM reveal white matter changes without associated gray matter changes in patients with idiopathic restless legs syndrome

Belke, Marcus; Heverhagen, Johannes; Keil, Boris; Rosenow, Felix; Oertel, Wolfgang H; Stiasny-Kolster, Karin; Knake, Susanne; Menzler, Katja (2015). DTI and VBM reveal white matter changes without associated gray matter changes in patients with idiopathic restless legs syndrome. Brain and Behavior, 5(9), e00327. Wiley 10.1002/brb3.327

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BACKGROUND AND PURPOSE We evaluated cerebral white and gray matter changes in patients with iRLS in order to shed light on the pathophysiology of this disease. METHODS Twelve patients with iRLS were compared to 12 age- and sex-matched controls using whole-head diffusion tensor imaging (DTI) and voxel-based morphometry (VBM) techniques. Evaluation of the DTI scans included the voxelwise analysis of the fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). RESULTS Diffusion tensor imaging revealed areas of altered FA in subcortical white matter bilaterally, mainly in temporal regions as well as in the right internal capsule, the pons, and the right cerebellum. These changes overlapped with changes in RD. Voxel-based morphometry did not reveal any gray matter alterations. CONCLUSIONS We showed altered diffusion properties in several white matter regions in patients with iRLS. White matter changes could mainly be attributed to changes in RD, a parameter thought to reflect altered myelination. Areas with altered white matter microstructure included areas in the internal capsule which include the corticospinal tract to the lower limbs, thereby supporting studies that suggest changes in sensorimotor pathways associated with RLS.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Heverhagen, Johannes

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2162-3279

Publisher:

Wiley

Language:

English

Submitter:

Aisha Stefania Mzinga

Date Deposited:

23 Mar 2016 12:16

Last Modified:

26 Mar 2016 12:32

Publisher DOI:

10.1002/brb3.327

PubMed ID:

26442748

Uncontrolled Keywords:

Diffusion tensor imaging; gray matter changes; restless legs syndrome; voxel-based morphometry; white matter changes

BORIS DOI:

10.7892/boris.77392

URI:

https://boris.unibe.ch/id/eprint/77392

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